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Spirulina Supplementation and Its Effects on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis on Randomized Clinical Trials Publisher



S Mousavi SAMIN ; A Yekdaneh AFSANEH ; M Shirani MAHSA ; A Feizi AWAZ ; Sm Ghanadian Seyed MUSTAFA
Authors

Source: Journal of Functional Foods Published:2025


Abstract

The study aimed to assess the effects of Spirulina as a supplementary treatment for inflammatory conditions amidst ongoing debates regarding its benefits for healthy individuals and patients. This systematic review and meta-analysis included 22 studies with 5385 participants, utilizing databases such as Scopus, Google Scholar, PubMed-Medline, and Web of Science, covering the period from 1995 to August 2024. The meta-analysis demonstrated that Spirulina supplementation significantly reduced inflammatory biomarkers, including CRP levels (SMD: −0.972 mg/dl), interleukin-6 (SMD: −0.532), and TNF-α (SMD: −0.579 mg/dl). Furthermore, oxidative stress biomarkers showed a significant decrease in malondialdehyde (SMD: −0.929) and an increase in total antioxidant capacity (SMD: 1.086). The findings strongly advocate for Spirulina as a valuable dietary supplement for both healthy individuals and patients, aiming to lower inflammatory markers and enhance antioxidant capacity. © 2025 Elsevier B.V., All rights reserved.
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