Relationship Between Hyperuricemia and the Severity of Coronary Artery Involvement in Patients With Acute Coronary Syndrome Publisher



Mirdamadi A ; Khoshnoud S ; Tabesh F ; Abdolrazaghnejad A
Source: Journal of Isfahan Medical School Published:2025

Abstract

Background: Given that the relationship between increased serum uric acid as a risk factor associated with cardiovascular diseases is still not clear. This study aimed to investigate the role of hyperuricemia in the severity of coronary artery involvement in patients with acute coronary syndrome. Methods: The current cross-sectional study was conducted on 114patients with cardiovascular diseases who referred to the Heart Clinic and Emergency Department of Khorshid Hospital in Isfahan. At the beginning of the study, their basic and clinical information such as age, gender, comorbidity, severity of coronary artery involvement and number of involved vessels were recorded. Also, the occurrence of acute coronary syndromes was recorded. Then, the serum uric acid level was measured and recorded after 12hours of fasting. Hyperuricemia was defined as a serum uric acid level of more than 7.5mg/dl in men and more than 6.5mg/dl in women. Findings: The mean serum uric acid level of these patients was 4.8 ± 1.5 mg/dl; so that 22(19.3%) were hyperuricemic and 92 (80.7%) were without hyperuricemia. In female patients, the frequency of hyperuricemia was significantly higher than in males (54.5% vs. 17.4%; P < 0.001). On the other hand, factors related to cardiovascular diseases such as severity of coronary artery involvement, number of involved vessels and coronary syndrome had no significant relationship with hyperuricemia (P > 0.05). Conclusion: According to the results of the present study, this study showed that serum uric acid level was not significantly associated with cardiovascular risk factors and severity of stenosis, number of involved vessels and type of coronary artery syndrome. © 2025 Elsevier B.V., All rights reserved.