Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Dapsone Gel in the Treatment of Papulopustular Rosacea: A Double-Blind Randomized Clinical Trial Pubmed



Faghihi G1 ; Khosravani P1 ; Nilforoushzadeh MA1, 2 ; Hosseini SM1 ; Assaf F1 ; Zeinali N1 ; Smiley A3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Poursina Clinic, Isfahan, Iran
  4. 4. Department of Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Drugs in Dermatology Published:2015


Abstract

Background: We aimed to evaluate the effects of 5% dapsone gel compared with 0.75% metronidazole gel in the treatment of papu-lopustular rosacea. Methods: In a double-blind randomized clinical trial, 56 adult patients with papulopustular rosacea were enrolled. The severity of disorder was determined by the patient according to visual analogue score (VAS). Investigator's global assessment (IGA) scores and number of inflammatory lesions were recorded. 5% dapsone gel was administered for group D and 0.75% metronidazole gel was administered for group M. Systemic doxycycline was administered for all patients. Follow-up assessments were done at 4, 8, and 12 weeks. Changes in VAS, IGA scores and number of lesions were evaluated. Intention to treat analysis was carried out using SPSS version 17 (Chicago, IL). Results: There was no significant difference in sex and age distribution between the two groups. Mean (SD) IGA score before and after intervention in group D was 3.9 (0.9) and 3.3 (0.9), respectively (P<0.0001). Mean (SD) IGA score before and after intervention in group M was 4.2 (1.2) and 3.6 (1.3), respectively (P<0.0001). Mean (SD) number of lesions before and after intervention in group D was 15 (7.4) and 11.1 (6), respectively (P<0.0001). Mean (SD) number of lesions before and after intervention in group M was 17.6 (7.7) and 12.5 (74), respectively (P<0.0001). Mean (SD) VAS score before and after intervention in group D was 6.6 (1.8) and 5.7 (1.9), respectively (P<0.0001). Mean (SD) VAS score before and after intervention in group M was 6.9 (2.0) and 5.3 (2.1), respectively (P<0.0001). Mean IGA score, mean number of lesions and mean VAS score were not significantly different between the two groups, whether before, during or after intervention. Conclusion: Dapsone gel was as effective as metronidazole gel in the treatment of papulopustular rosacea. Copyright © 2015 JOURNAL OF DRUGS IN DERMATOLOGY.
Related Docs
1. Comparison of Efficacy Between Permethrin 5% Cream and Ivermectin 1% Cream in Combination With Oral Doxycycline in Treatment of Papulopustular Rosacea Patients; [مقایسهی تأثیر کرم پرمترین 5 % همراه با داکسیسیکلین خوراکی با کرم ایورمکتین 1 % همراه با داکسیسیکلین خوراکی در درمان بیماران مبتلا به روزاسه پاپولوپوسچولار], Journal of Isfahan Medical School (2024)
2. Evaluation of the Effectiveness of Topical Zinc Acetate 1.2% for Pruritus and Erythema of Seborrheic Dermatitis in Patients Under Treatment With Ketoconazole 2% Solution, Journal of Isfahan Medical School (2016)
3. The Efficacy of 1% Metronidazole Gel in Facial Seborrheic Dermatitis: A Double Blind Study, Indian Journal of Dermatology, Venereology and Leprology (2006)
4. Association Between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection, Advanced Biomedical Research (2023)
Experts (# of related papers)
View all Related Experts
Gita Faghihi (2)
Zabihollah Shahmoradi (2)