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Antihypertensive Effect of Lactoferrin on Dexamethasone-Induced Hypertension in Rat



Safaeian L1 ; Zabolian H2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2013

Abstract

Background: Dexamethasone-induced hypertension is one of the animal models of hypertension. Lactoferrin is a natural iron-binding protein with proposed antihypertensive effects. In this study, the effect of chronic use of lactoferrin was investigated on dexamethasone-induced hypertension in rat and compared with captopril. Methods: In this experimental study, hypertension was induced by subcutaneously injection of dexamethasone (30 μg/kg/day) for 15 days in Wistar rat. Lactoferrin (300 mg/kg) and captopril (40 mg/kg) were orally given from the day 8 to 15. Systolic blood pressure was measured by tail cuff. Body weight was measured during experiment and thymus weight was detected as a marker of glucocorticoid activity at the end of study. Findings: Administration of dexamethasone increased systolic blood pressure (115.6 + 3.3 to 150.1 + 7.4 mmHg) and decreased body and thymus weight (P < 0.05). Chronic administration of lactoferrin and captopril for one week decreased systolic blood pressure (P < 0.01 for both). Lactoferrin also prevented body weight loss. Conclusion: The results indicated antihypertensive effect of lactoferrin on dexamethasone-induced hypertension. Further studies are suggested for finding the mechanism of lactoferrin in this model of hypertension.
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