Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Nose to Brain Delivery of Ibudilast Micelles for Treatment of Multiple Sclerosis in an Experimental Autoimmune Encephalomyelitis Animal Model Publisher Pubmed



Sharifian A1 ; Varshosaz J1 ; Aliomrani M2 ; Kazemi M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Novel Drug Delivery Systems Research Centre, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Genetics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Pharmaceutics Published:2023


Abstract

Multiple sclerosis is a chronic inflammatory disease of the central nervous system ultimate to neurodegeneration and demyelination. Ibudilast is a phosphodiesterase inhibitor, effective on the function of glial cells and lymphocytes, and inhibits the release of TNF-α by inflammatory cells. Dysregulation of glia is one of the most important pathological causes of MS. Therefore, ibudilast as a glial attenuator can be a useful treatment. The objective of the present study was to investigate the effect of nasal spray of polydopamine coated micelles of surfactin, a biosurfactant, loaded with ibudilast on its brain targeted delivery and effectiveness in remylination and neuroprotection in animal model of MS. In animal studies the micelles were administrated intranasally in different doses of 10, 25 and 50 mg/kg/day in C57/BL6 mice immunized by experimental autoimmune encephalomyelitis (EAE) model. The results of Luxol fast blue staining indicated increment in myelin fiber percent more significantly (p < 0.05) in the groups treated with the polydopamine coated micelles (PDAM) compared to nasal spray of free drug or oral administration. These formulations also increased expression of Mbp, Olig2 and Mog genes in the corpus callosum. These results suggest a positive outcome of polydopamine coated micelles loaded with ibudilast in active MS as an anti-inflammatory and neuroprotective agent. © 2023
Related Docs
View other Related Docs
1. Polydopamine Coated Surfactin Micelles for Brain Delivery of Ibudilast in Multiple Sclerosis: Design, Optimization, in Vitro and in Vivo Evaluation, Journal of Drug Delivery Science and Technology (2024)
2. Masitinib: The Promising Actor in the Next Season of the Amyotrophic Lateral Sclerosis Treatment Series, Biomedicine and Pharmacotherapy (2023)
3. The Role of Distinct Subsets of Macrophages in the Pathogenesis of Ms and the Impact of Different Therapeutic Agents on These Populations, Frontiers in Immunology (2021)
4. Immunomodulatory Effects of Cyclotides Isolated From Viola Odorata in an Experimental Autoimmune Encephalomyelitis Animal Model of Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2022)
5. The Preventive Effect of Zingiber Officinale Essential Oil on Demyelination of Corpus Callosum in a Cuprizone Rat Model of Multiple Sclerosis, Avicenna Journal of Phytomedicine (2023)
6. Effects of Asparagus Officinalis on Immune System Mediated Eae Model of Multiple Sclerosis, Toxicology Research (2022)
7. Hybrid Derivatives Containing Dimethyl Fumarate and Benzothiazole Scaffolds for the Potential Treatment of Multiple Sclerosis; in Silico & in Vivo Study, DARU, Journal of Pharmaceutical Sciences (2024)
8. Multiple Sclerosis (Ms) and Neuromyelitis Optica Spectrum Disorder (Nmosd) Following Covid-19 Vaccines: A Systematic Review, Revue Neurologique (2023)
Experts (# of related papers)
View all Related Experts
Nazem Ghasemi (12)
Mehdi Aliomrani (9)
Other Related Docs
9. Establishment of Experimental Autoimmune Encephalitis Model by Injection of Different Combination of Homogenized Brain Tissue of Rat With Cfa, Journal of Isfahan Medical School (2012)
10. Improvement of Remyelination in Demyelinated Corpus Callosum Using Human Adipose-Derived Stem Cells (Hadscs) and Pregnenolone in the Cuprizone Rat Model of Multiple Sclerosis, Journal of Molecular Neuroscience (2020)
11. Evaluation of Edaravone Effects on the Differentiation of Human Adipose Derived Stem Cells Into Oligodendrocyte Cells in Multiple Sclerosis Disease in Rats, Life Sciences (2021)
12. Evaluation of in Vivo Lithium Chloride Effects As a Gsk3-Β Inhibitor on Human Adipose Derived Stem Cells Differentiation Into Oligodendrocytes and Re-Myelination in an Animal Model of Multiple Sclerosis, Molecular Biology Reports (2023)
13. Multiple Sclerosis: Clinical Features, Pathophysiology, Neuroimaging and Future Therapies, Future Neurology (2009)
14. A Novel Approach to Discriminate Subgroups in Multiple Sclerosis, Iranian Journal of Allergy, Asthma and Immunology (2016)
15. Bee Venom–Derived Bbb Shuttle and Its Correlation With Oligodendrocyte Proliferation Markers in Mice Model of Multiple Sclerosis, Neurotoxicity Research (2021)
16. Hydroxycitric Acid Ameliorates Inflammation and Oxidative Stress in Mouse Models of Multiple Sclerosis, Neural Regeneration Research (2016)
17. Mannose-Binding Lectin Mediated Complement Pathway in Autoimmune Neurological Disorders, Iranian Journal of Allergy, Asthma and Immunology (2016)
18. Possible Regenerative Effects of Fingolimod (Fty720) in Multiple Sclerosis Disease: An Overview on Remyelination Process, Journal of Neuroscience Research (2020)
19. Hydroxychloroquine Effects on Mir-155-3P and Mir-219 Expression Changes in Animal Model of Multiple Sclerosis, Metabolic Brain Disease (2020)
20. The Effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis, Iranian Biomedical Journal (2022)
21. Effect of Swimming on Oligodendrocytic Cells and Myelin Tissue in Corpus Callosum of Rat Model of Ms Induced by Cuprizone, Medical Journal of Tabriz University of Medical Sciences (2021)
22. Transplantation of Human Adipose-Derived Stem Cells Overexpressing Lif/Ifn-Β Promotes Recovery in Experimental Autoimmune Encephalomyelitis (Eae), Scientific Reports (2022)
23. The Dose-Dependent Neuroprotective Effect of Norepinephrine in Improving Memory Retrieval in an Experimental Model of Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Brain Research Bulletin (2024)
24. The Role of Immune Regulatory Molecules in Multiple Sclerosis, Journal of Neuroimmunology (2019)
25. Variability of the Response to Immunotherapy Among Subgroups of Patients With Multiple Sclerosis, European Journal of Neurology (2023)
26. The Immunoregulatory and Neuroprotective Effects of Human Adipose Derived Stem Cells Overexpressing Il-11 and Il-13 in the Experimental Autoimmune Encephalomyelitis Mice, International Immunopharmacology (2020)
27. Comparative Analysis of Apigenin-3 Acetate Versus Apigenin and Methyl-Prednisolone in Inhibiting Proliferation and Gene Expression of Th1 Cells in Multiple Sclerosis, Cell Journal (2023)
28. Evaluation of Apamin Effects on Myelination Process in C57bl/6 Mice Model of Multiple Sclerosis, Research in Pharmaceutical Sciences (2019)
29. Astaxanthin Reduces Demyelination and Oligodendrocytes Death in a Rat Model of Multiple Sclerosis, Cell Journal (2021)
30. Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy, Cell Journal (2017)
31. Impact of Intraventricular Human Adipose-Derived Stem Cells Transplantation With Pregnenolone Treatment on Remyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis, Cell Journal (2022)
32. Analysis of Platelet-Derived Growth Factor Receptor a and Oligodendrocyte Transcription Factor 2 Markers Following Hydroxychloroquine Administration in Animal Induced Multiple Sclerosis Model, Metabolic Brain Disease (2021)
33. Co-Transplantation of Human Neurotrophic Factor Secreting Cells and Adipose-Derived Stem Cells in Rat Model of Multiple Sclerosis, Cell Journal (2018)
34. Glutathione Targeted Tragacanthic Acid-Chitosan As a Non-Viral Vector for Brain Delivery of Mirna-219A-5P: An in Vitro/In Vivo Study, International Journal of Biological Macromolecules (2022)
35. Human Placental Extract Attenuates Neurological Symptoms in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis-A Putative Approach in Ms Disease?, Autoimmunity Highlights (2020)
36. Transplantation of Human Adipose-Derived Stem Cells Enhances Remyelination in Lysolecithin-Induced Focal Demyelination of Rat Spinal Cord, Molecular Biotechnology (2014)