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The Association Between Serum Vitamin D, Fertility and Semen Quality: A Systematic Review and Meta-Analysis Publisher Pubmed



Arab A1 ; Hadi A2 ; Moosavian SP3 ; Askari G1 ; Nasirian M4
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Halal Research Center of IRI, FDA, Tehran, Iran
  3. 3. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Faculty of biostatistics and epidemiology, Isfahan university of medical sciences, Isfahan, Iran

Source: International Journal of Surgery Published:2019


Abstract

Purpose: A number of studies have examined the association between vitamin D, fertility and semen quality, however, findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between vitamin D, fertility and semen quality in adult population. Methods: PubMed, Cochrane's Library, Science Direct, Scopus, Google Scholar and ISI Web of Science databases were searched until December 2018 for all available studies evaluating the association between vitamin D, fertility and semen quality. The Newcastle-Ottawa Quality Assessment Scale was used to examine the quality of each study. Results: A total of 18 studies out of 1843 met our inclusion criteria and were included in our systematic review and meta-analysis. Serum 25(OH)D3 was significantly higher in fertile subjects compared to infertile ones (WMD -0.63; 95% CI, −1.06 to −0.21; P = 0.003). Furthermore, there was a significant association between serum 25(OH)D, sperm motility (WMD -5.84; 95% CI, −10.29 to −1.39; P = 0.01) and sperm progressive motility (WMD -5.24; 95% CI, −8.71 to −1.76; P = 0.003). Conclusion: Our findings add to the existing literature supporting the concept that nutrition, especially vitamin D, plays an important role in men's sexual health. It should be noted that because of significant heterogeneity among the included studies, caution is warranted when interpreting the results. Further well-designed prospective cohort studies and clinical trials are needed for better understanding of the relationship between vitamin D and fertility and its components. © 2019
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