The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo

The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo Pubmed

Hejazi H¹ ; Eslami G² ; Dalimi A²

Source: Annals of Tropical Medicine and Parasitology Published:2004

Abstract

The effects of low electrical potentials on Leishmania major (MRHO/IR/75/ER) were investigated both in culture (in terms of promastigote viability) and in experimentally infected BALB/c and NMRI mice (in terms of the cure of pre-existing skin lesions). Exposure to direct-current potentials of 3, 6, 9 and 12 V (at 0.2-10.7 mA) killed all promastigotes in < 15, < 10, < 10 and < 10 min, respectively. When electrodes were used to pass similar direct currents across skin lesions on the tails of infected mice, all but the lowest voltage (3 V) caused unwanted ulceration. At 3 V, however, 3 weeks of electrotherapy, for 10 min twice weekly, initially appeared to cure all the lesions and the therapy was then halted. If given no electrotherapy, the BALB/c mice showed much greater Leishmania-attributable morbidity and mortality than the NMRI mice, and it was only in the treated BALB/c mice that relapses were observed, about 3 weeks after electrotherapy had ceased. The possible clinical use of electrotherapy in the treatment of human cutaneous leishmaniasis is discussed.

Style	Citing Format
MLA	Hejazi H, Eslami G, Dalimi A. "The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo." Annals of Tropical Medicine and Parasitology, vol. 98, no. 1, 2004, pp. 37-42.
APA	Hejazi H, Eslami G, Dalimi A (2004). The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo. Annals of Tropical Medicine and Parasitology, 98(1), 37-42.
Chicago	Hejazi H, Eslami G, Dalimi A. "The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo." Annals of Tropical Medicine and Parasitology 98, no. 1 (2004): 37-42.
Harvard	Hejazi H, Eslami G, Dalimi A (2004) 'The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo', Annals of Tropical Medicine and Parasitology, 98(1), pp. 37-42.
Vancouver	Hejazi H, Eslami G, Dalimi A. The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo. Annals of Tropical Medicine and Parasitology. 2004;98(1):37-42.
BibTex	@article{ author = {Hejazi H and Eslami G and Dalimi A}, title = {The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo}, journal = {Annals of Tropical Medicine and Parasitology}, volume = {98}, number = {1}, pages = {37-42}, year = {2004} }
RIS	TY - JOUR AU - Hejazi H AU - Eslami G AU - Dalimi A TI - The Parasiticidal Effect of Electricity on Leishmania Major, Both in Vitro and in Vivo JO - Annals of Tropical Medicine and Parasitology VL - 98 IS - 1 SP - 37 EP - 42 PY - 2004 ER -

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