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Role of Platelets in Neuroinflammation: A Wide-Angle Perspective Publisher Pubmed



Horstman LL1 ; Jy W1 ; Ahn YS1 ; Zivadinov R2 ; Maghzi AH3 ; Etemadifar M3 ; Steven Alexander J4 ; Minagar A5
Authors
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Authors Affiliations
  1. 1. Wallace Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, United States
  2. 2. Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, State University of New York at Buffalo, Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo NY, United States
  3. 3. Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Cellular and Molecular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, United States
  5. 5. Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, United States

Source: Journal of Neuroinflammation Published:2010


Abstract

Objectives: This review summarizes recent developments in platelet biology relevant to neuroinflammatory disorders. Multiple sclerosis (MS) is taken as the Poster Child of these disorders but the implications are wide. The role of platelets in inflammation is well appreciated in the cardiovascular and cancer research communities but appears to be relatively neglected in neurological research.Organization: After a brief introduction to platelets, topics covered include the matrix metalloproteinases, platelet chemokines, cytokines and growth factors, the recent finding of platelet PPAR receptors and Toll-like receptors, complement, bioactive lipids, and other agents/functions likely to be relevant in neuroinflammatory diseases. Each section cites literature linking the topic to areas of active research in MS or other disorders, including especially Alzheimer's disease.Conclusion: The final section summarizes evidence of platelet involvement in MS. The general conclusion is that platelets may be key players in MS and related disorders, and warrant more attention in neurological research. © 2010 Horstman et al; licensee BioMed Central Ltd.
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