Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparing the Efficacy of Escitalopram With and Without Crocin in Restoring I/O Functions and Ltp Within the Hippocampal Ca1 Region of Stressed Rats Publisher



Joodaki M1 ; Radahmadi M1 ; Alaei H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Advanced Biomedical Research Published:2024


Abstract

Background: Escitalopram, a pharmacological compound, and crocin, the active compound of saffron, influence brain functions and serotonin levels. This study examined the efficacy of escitalopram with and without crocin in restoring the input‑output (I/O) functions and long‑term potentiation (LTP) within the hippocampal cornu ammonis 1 (CA1) region of stressed rats. Materials and Methods: Rats were divided into six groups: control (Co), sham (Sh), stress‑recovery (St‑Rec), stress‑escitalopram (St‑Esc), stress‑crocin (St‑Cr), and stress‑escitalopram‑crocin (St‑Esc‑Cr) groups. They underwent 14 days of restraint stress (6 h/day). After being subjected to stress, they received 14 days of escitalopram (20 mg/kg) and crocin (30 mg/kg), as well as co‑administration of these two compounds during the next 14 days. The field excitatory postsynaptic potential (fEPSP) slope and amplitude were measured using I/O functions and LTP induction in the CA1 region. Corticosterone (CORT) levels were also evaluated. Results: The fEPSPs slope and amplitude in the I/O functions and LTP induction significantly decreased in stressed rats without therapeutic intervention. These variables in the I/O functions declined in rats with escitalopram administration alone. All electrophysiological parameters showed an increase in rats treated with crocin alone compared to stressed subjects without any treatment. Serum CORT levels decreased only with crocin treatment for stressed rats. Conclusion: Neural excitability and memory within the CA1 region were severely disrupted among stressed rats without any treatment. Furthermore, administering crocin alone improved neural excitability and memory post‑chronic stress. Treatment with escitalopram alone also impaired neural excitability within the CA1 region. The use of escitalopram with and without crocin did not enhance memory under chronic stress. © 2024 Advanced Biomedical Research.
Related Docs
View other Related Docs
1. Comparing the Therapeutic Effects of Crocin, Escitalopram and Co-Administration of Escitalopram and Crocin on Learning and Memory in Rats With Stress-Induced Depression, Malaysian Journal of Medical Sciences (2021)
2. Protective Effects of Long-Term Escitalopram Administration on Memory and Hippocampal Bdnf and Bcl-2 Gene Expressions in Rats Exposed to Predictable and Unpredictable Chronic Mild Stress, Brain Sciences (2024)
3. The Protective Effects of Crocin on Input-Output Functions and Long-Term Potentiation of Hippocampal Ca1 Area in Rats Exposed to Chronic Social Isolated Stress, Basic and Clinical Neuroscience (2022)
4. Comparing the Effects of Crocin at Different Doses on Excitability and Long-Term Potentiation in the Ca1 Area, As Well As the Electroencephalogram Responses of Rats Under Chronic Stress, Metabolic Brain Disease (2021)
5. The Protective Effects of Escitalopram on Synaptic Plasticity in the Ca1 Region of Chronically Stressed and Non-Stressed Male Rats, International Journal of Developmental Neuroscience (2022)
6. Therapeutic Effects of Exercise-Accompanied Escitalopram on Synaptic Potency and Long-Term Plasticity in the Hippocampal Ca1 Area in Rats Under Chronic Restraint Stress, Iranian Journal of Basic Medical Sciences (2022)
7. Effects of Prolonged Escitalopram Administration on Long-Term Potentiation Within the Hippocampal Ca1 Area in Rats Under Predictable and Unpredictable Chronic Mild Stress, Metabolic Brain Disease (2024)
8. Comparative Study of the Protective Effects of Crocin and Exercise on Long-Term Potentiation of Ca1 in Rats Under Chronic Unpredictable Stress, Life Sciences (2020)
Experts (# of related papers)
View all Related Experts
Maryam Radahmadi (36)
Hojatallah Alaei (24)
Other Related Docs
9. Comparative Evaluation of Antidepressant and Anxiolytic Effects of Escitalopram, Crocin, and Their Combination in Rats, Advanced Biomedical Research (2024)
10. Therapeutic Effects of Exercise, Escitalopram and Exercise-Accompanied Escitalopram on Brain Functions in Rats With Depression, Physiology and Pharmacology (Iran) (2022)
11. The Protective Effects of Escitalopram on Chronic Restraint Stress-Induced Memory Deficits in Adult Rats, Physiology and Pharmacology (Iran) (2022)
12. The Impact of Crocin and Chronic Isolation Stress on Passive Avoidance Memory and Brain Electrical Activity in Male Rats, Physiology and Pharmacology (Iran) (2022)
13. The Impact of Different Dark Chocolate Dietary Patterns on Synaptic Potency and Plasticity in the Hippocampal Ca1 Area of the Rats Under Chronic Isolation Stress, Nutritional Neuroscience (2023)
14. Effect of Chronic Stress on Short and Long-Term Plasticity in Dentate Gyrus; Study of Recovery and Adaptation, Neuroscience (2014)
15. Effects of Crocin on Cognitive and Spatial Memories in Rats Under Chronic Isolation Stress, Physiology and Pharmacology (Iran) (2018)
16. In Vivo Synaptic Potency, Short-Term and Long-Term Plasticity at the Hippocampal Schaffer Collateral-Ca1 Synapses: Role of Different Light–Dark Cycles in Male Rats, Brain Research (2023)
17. Comparing Various Types of Chronic Psychological Stress on Cognitive Functions and Behaviors in Rats, Basic and Clinical Neuroscience (2024)
18. The Effects of Subchronic Social and Isolation Stresses on Learning and Memory Trend in Male Rats, Physiology and Pharmacology (Iran) (2018)
19. Therapeutic Effects of Saffron Extract on Different Memory Types, Anxiety, and Hippocampal Bdnf and Tnf-Α Gene Expressions in Sub-Chronically Stressed Rats, Nutritional Neuroscience (2022)
20. Effects of Crocin on Locomotor Activity As Well As Novel Object Recognition and Object Location Memories in Chronic Restraint Stressed Rats, Physiology and Pharmacology (Iran) (2020)
21. Effects of Stress on Serum and Hippocampal Il-1Β and Glucose Levels As Well As Retention in Rats, Indian Journal of Physiology and Pharmacology (2017)
22. Effects of Chronic Empathic Stress on Synaptic Efficacy, As Well As Short-Term and Long-Term Plasticity at the Schaffer Collateral/Commissural– Ca1 Synapses in the Dorsal Hippocampus of Rats, Metabolic Brain Disease (2025)
23. Crocin Improves Cognitive Impairment in Lps-Treated Rats Through Anti-Apoptotic, Anti-Inflammatory, and Antioxidant Activities, Molecular Neurobiology (2024)
24. Effects of Crocin on Spatial or Aversive Learning and Memory Impairments Induced by Lipopolysaccharide in Rats, Avicenna Journal of Phytomedicine (2021)
25. Effects of Different Dark Chocolate Diets on Memory Functions and Brain Corticosterone Levels in Rats Under Chronic Stress, Physiology and Pharmacology (Iran) (2020)
26. Effects of Chronic Social Equality and Inequality Conditions on Passive Avoidance Memory and Ptsd-Like Behaviors in Rats Under Chronic Empathic Stress, International Journal of Neuroscience (2024)
27. Effect of Exercise, Exercise Withdrawal, and Continued Regular Exercise on Excitability and Long-Term Potentiation in the Dentate Gyrus of Hippocampus, Brain Research (2016)
28. Doxepin Improves Stress-Impaired Long-Term Potentiation and Gene Expression of Bdnf in the Rat Hippocampus, Physiology and Pharmacology (2016)
29. The Effect of Basolateral Amygdala Nucleus Lesion on Memory Under Acute, Mid and Chronic Stress in Male Rats, Turkish Journal of Medical Sciences (2016)
30. D-Lys-3-Ghrp-6 Impairs Memory Consolidation and Downregulates the Hippocampal Serotonin Ht1a, Ht7 Receptors and Glutamate Glua1 Subunit of Ampa Receptors, Physiology and Behavior (2020)
31. The Effects of Cck-8S on Spatial Memory and Long-Term Potentiation at Ca1 During Induction of Stress in Rats, Iranian Journal of Basic Medical Sciences (2017)
32. The Effects of Nbm- Lesion on Synaptic Plasticity in Rats, Brain Research (2017)
33. The Effects of Acorus Calamus L. in Preventing Memory Loss, Anxiety, and Oxidative Stress on Lipopolysaccharide-Induced Neuroinflammation Rat Models, International Journal of Preventive Medicine (2018)
34. Effects of Amitriptyline and Fluoxetine on Synaptic Plasticity and Tnf-Α Level at Hippocampus of Streptozotocin-Induced Diabetic Rats, Physiology and Pharmacology (2017)
35. The Effect of the Blockage of the Receptors of Glutamate N-Methyl-D-Aspartate (Nmda) in Prefrontal Cortex on Morphine Tendency in Male Rat, Journal of Isfahan Medical School (2016)
36. Pretreatment With Crocin Along With Treadmill Exercise Ameliorates Motor and Memory Deficits in Hemiparkinsonian Rats by Anti-Inflammatory and Antioxidant Mechanisms, Metabolic Brain Disease (2019)
37. Saffron (Crocus Sativus L.) Extract Prevents and Improves D-Galactose and Nano 2 Induced Memory Impairment in Mice, EXCLI Journal (2012)
38. Impact of Combined Forced Exercise With Escitalopram on Stress-Induced Depressive-Like Behavior in Male Rats, Journal of Advances in Medical and Biomedical Research (2024)
39. The Effects of Acute, Sub-Chronic and Chronic Psychical Stress on the Brain Electrical Activity in Male Rats, Physiology and Pharmacology (Iran) (2017)
40. Therapeutic Effects of Saffron and Its Components on Neurodegenerative Diseases, Heliyon (2024)
41. Effects of Crocin on Brain Oxidative Damage and Aversive Memory in a 6-Ohda Model of Parkinson’S Disease; [Efeitos Da Crocina No Dano Oxidativo Cerebral E Na Memoria Aversiva Em Um Modelo 6-Ohda De Doenca De Parkinson], Arquivos de Neuro-Psiquiatria (2016)
42. Effect of Forced Treadmill Exercise on Stimulation of Bdnf Expression, Depression Symptoms, Tactile Memory and Working Memory in Lps-Treated Rats, Behavioural Brain Research (2022)
43. Effects of Different Timing of Stress on Corticosterone, Bdnf and Memory in Male Rats, Physiology and Behavior (2015)
44. Preventive and Therapeutic Effect of Treadmill Running on Chronic Stress-Induced Memory Deficit in Rats, Journal of Bodywork and Movement Therapies (2015)
45. Effects of Crocin on Rotational Behavior, Lipid Peroxidation and Nitrite Levels in Rat’S Brain Striatum in an Experimental Model of Parkinson's Disease, Journal of Isfahan Medical School (2015)
46. The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal Memory Mediators in Stressed Rats, Malaysian Journal of Medical Sciences (2016)
47. Different Current Intensities Electrical Stimulation of Prelimbic Cortex of Mpfc Produces Different Effects on Morphine-Induced Conditioned Place Preference in Rats, Behavioural Brain Research (2012)
48. Stress Biomarker Responses to Different Protocols of Forced Exercise in Chronically Stressed Rats, Journal of Bodywork and Movement Therapies (2017)