Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Correlation Between Zinc Nutritional Status With Serum Zonulin and Gastrointestinal Symptoms in Diarrhea-Predominant Irritable Bowel Syndrome: A Case–Control Study Publisher Pubmed



Rezazadegan M1 ; Soheilipour M2 ; Tarrahi MJ3 ; Amani R1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Digestive Diseases and Sciences Published:2022


Abstract

Background: Zinc is known to have a critical role in the maintenance of intestinal homeostasis, immune cells, and anti-diarrheal and anti-inflammatory actions. Aims: The aim of this study was to evaluate the correlation between zinc status with serum zonulin and gastrointestinal symptoms in diarrhea-predominant patients with irritable bowel syndrome (IBS-D). Methods: This case–control study included 61 newly diagnosed IBS-D patients and 61 healthy matched controls. Dietary zinc intake, serum zinc, and zonulin levels were measured. IBS severity was evaluated using the IBS severity score system (IBS-SSS) questionnaire. Results: Serum zinc levels were lower in the IBS-D group compared with the controls (p = 0.001). Serum zinc was negatively correlated with serum zonulin in IBS-D patients (r = − 0.271; p = 0.035). Also, a reverse association between the serum zinc and odds of IBS-D was found [OR = 0.979; 95% CI (0.966–0.992)]. Conclusions: Our results suggest that zinc may have a role in the pathogenesis of IBS. However, clinical trial studies are warranted to evaluate this finding. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Related Docs
View other Related Docs
1. Zinc Nutritional Status, Mood States and Quality of Life in Diarrhea-Predominant Irritable Bowel Syndrome: A Case–Control Study, Scientific Reports (2022)
2. The Relationship of Plasma Zinc Concentration and Hepatic Encephalopathy in Patients With Cirrhosis, Journal of Isfahan Medical School (2014)
3. The Association Between Dietary Total Antioxidant Capacity and Odds and Severity of Irritable Bowel Syndrome Among Iranian Adults: A Cross-Sectional Study, BMC Gastroenterology (2022)
4. Effect of Zinc Supplementation on Mortality in Under 5-Year Children: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, European Journal of Nutrition (2022)
5. Adherence to the Pro-Inflammatory Diet in Relation to Prevalence of Irritable Bowel Syndrome, Nutrition Journal (2019)
6. Vitamin D3 Induced Decrease in Il-17 and Malondialdehyde, and Increase in Il-10 and Total Antioxidant Capacity Levels in Patients With Irritable Bowel Syndrome, Iranian Journal of Immunology (2018)
7. The Effect of Zinc Sulfate on Acute Diarrhea in Children Based on the Socioeconomic Status of Parents in Isfahan City, Iran, Journal of Isfahan Medical School (2019)
8. The Comparison of Serum Zinc Level in Behcet Patients and Healthy Controls, Journal of Isfahan Medical School (2009)
Experts (# of related papers)
View all Related Experts
Reza Amani (12)
Roya Kelishadi (11)
Other Related Docs
9. Zinc and Its Importance for Human Health: An Integrative Review, Journal of Research in Medical Sciences (2013)
10. Effects of Zinc Supplementation on Inflammatory Biomarkers and Oxidative Stress in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Trace Elements in Medicine and Biology (2021)
11. Zinc Status As Compared to Zinc Intake and Iron Status: A Case Study of Iranian Populations From Isfahan Province, International Journal for Vitamin and Nutrition Research (2013)
12. Zinc and Copper Status in Children With High Family Risk of Premature Cardiovascular Disease, Annals of Saudi Medicine (2002)
13. Dietary Intake of Phytochemicals in Association With Irritable Bowel Syndrome in Adults, Clinical Nutrition ESPEN (2023)
14. The Relationship of Serum Vitamin D and Zinc in a Nationally Representative Sample of Iranian Children and Adolescents: The Caspian-Iii Study, Medical Journal of the Islamic Republic of Iran (2016)
15. Serum Zinc Level and Its Association With Pulmonary Tuberculosis, Immunopathologia Persa (2025)
16. The Effects of Zinc Supplementation on Metabolic Profile and Oxidative Stress in Overweight/Obese Patients With Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Trace Elements in Medicine and Biology (2020)
17. The Effects of Zinc Acetate Capsule on the Intensity of Primary Dysmenorrhea: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Iranian Journal of Obstetrics, Gynecology and Infertility (2016)
18. A Systematic Review and Meta-Analysis on the Prevalence of Zinc Deficiency in Iranian Population, Journal of Pediatrics Review (2023)
19. Metabolomics Analysis Revealed Metabolic Changes in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Metabolic Responses to a Synbiotic Yogurt Intervention, European Journal of Nutrition (2019)
20. Percentile Values of Serum Zinc Concentration and Prevalence of Its Deficiency in Iranian Children and Adolescents: The Caspian-V Study, Journal of Pediatric Endocrinology and Metabolism (2020)
21. The Effect of Zinc Supplementation on Steatosis Severity and Liver Function Enzymes in Overweight/Obese Patients With Mild to Moderate Non-Alcoholic Fatty Liver Following Calorie-Restricted Diet: A Double-Blind, Randomized Placebo-Controlled Trial, Biological Trace Element Research (2020)
22. Serum Zinc Levels in Hemodialysis and Peritoneal Dialysis Patients: A Retrospective Observational Study, Journal of Research in Medical Sciences (2024)
23. Vitamin D Deficiency Associated With Disease Activity in Patients With Inflammatory Bowel Diseases, Digestive Diseases and Sciences (2015)
24. Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome, Journal of the American College of Nutrition (2019)
25. Low Serum Zinc Level in Depression, Journal of Research in Medical Sciences (2006)
26. High Prevalence of Goiter in Schoolchildren in Isfahan; Zinc Deficiency Does Not Play a Role, Endokrynologia Polska (2010)
27. Epidemiological Features of Irritable Bowel Syndrome and Its Subtypes Among Iranian Adults, Annals of Gastroenterology (2015)
28. The Effect of Zinc Supplementation on Brain Derived Neurotrophic Factor: A Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2021)
29. Clinical Effectiveness of Zinc Supplementation on the Biomarkers of Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2020)
30. Effect of Consuming Zinc-Fortified Bread on Serum Zinc and Iron Status of Zinc-Deficient Women: A Double Blind, Randomized Clinical Trial, International Journal of Preventive Medicine (2012)
31. Effects of Vitamin D Supplementation on Serum 25‑Hydroxy Cholecalciferol in Inflammatory Bowel Diseases: A Meta‑Analysis of Randomized Clinical Trials, International Journal of Preventive Medicine (2024)
32. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study, Gastroenterology (2021)
33. Comparison and Assessment of Flixweed and Fig Effects on Irritable Bowel Syndrome With Predominant Constipation: A Single-Blind Randomized Clinical Trial, Explore (2019)
34. Effects of Zinc Supplementation on Subscales of Anorexia in Children: A Randomized Controlled Trial, Pakistan Journal of Medical Sciences (2014)
35. The Effect of Zinc Supplementation on Blood Pressure: A Systematic Review and Dose–Response Meta-Analysis of Randomized-Controlled Trials, European Journal of Nutrition (2020)
36. Zinc Status and Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis, Journal of Trace Elements in Medicine and Biology (2019)
37. Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and Meta-Analyses of Randomized Clinical Trials, Nutrition Reviews (2025)
38. Sex-Related Differences in Clinical Symptoms, Quality of Life, and Biochemical Factors in Irritable Bowel Syndrome, Digestive Diseases and Sciences (2017)
39. Association of Mood Disorders With Serum Zinc Concentrations in Adolescent Female Students, Biological Trace Element Research (2017)
40. Effect of Zinc Supplementation on Symptoms and C-Reactive Protein Among Patients With Migraine: A Double-Blind Randomized Placebo-Controlled Clinical Trial, Journal of Health System Research (2020)
41. Effect of Zinc Supplementation on Glycemic Biomarkers: An Umbrella of Interventional Meta-Analyses, Diabetology and Metabolic Syndrome (2024)
42. Effect of Zinc Supplementation on Physical and Psychological Symptoms, Biomarkers of Inflammation, Oxidative Stress, and Brain-Derived Neurotrophic Factor in Young Women With Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial, Biological Trace Element Research (2020)
43. Inflammatory Cytokines and Oxidative Stress Biomarkers in Irritable Bowel Syndrome: Association With Digestive Symptoms and Quality of Life, Cytokine (2017)
44. Effect of Zinc Supplementation on Markers of Insulin Resistance, Oxidative Stress, and Inflammation Among Prepubescent Children With Metabolic Syndrome, Metabolic Syndrome and Related Disorders (2010)
45. The Association Between Meal and Snack Frequency and Irritable Bowel Syndrome, Public Health Nutrition (2021)
46. Face-To-Face Interviews Versus Internet Surveys: Comparison of Two Data Collection Methods in the Rome Foundation Global Epidemiology Study: Implications for Population-Based Research, Neurogastroenterology and Motility (2023)
47. The Effect of Zinc Supplementation on Lipid Profiles in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Dose–Response Meta-Analysis of Randomized Clinical Trials, Advances in Nutrition (2023)
48. Empirically Derived Food-Based Inflammatory Potential of the Diet, Irritable Bowel Syndrome, and Its Severity, Nutrition (2019)
49. Does the Serum Zinc Level Affect the Quality of Life in Dialysis Patients? a Report From Iran, Nephro-Urology Monthly (2024)
50. The Association of Zinc Serum Level With Age, Sex and Disease Severity in Acne Vulgaris Patients, Journal of Isfahan Medical School (2012)