An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor

An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor Publisher Pubmed

Jahani MM¹ ; Azimi Meibody A² ; Karimi T³ ; Banoei MM⁴ ; Houshmand M^{3, 5}

Show Affiliations

1. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Emergency Medicine, Faculty of Medicine, University of Isfahan, Isfahan, Iran
3. Department of Medical Genetic, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran
4. Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
5. Research Center, Knowledge University, Erbil, Kurdistan Region, Iraq

Source: Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis Published:2020

Abstract

Breast cancer is the most common malignancy and the second leading cause of cancer deaths among women worldwide after lung cancer. Mitochondria play a central role in the regulation of cellular function, metabolism, and cell death in cancer cells. We aim to examine the mitochondrial polymorphisms of complex I in association with breast cancer in an Iranian cohort. This experimental study includes 53 patients with breast cancer and 35 healthy control patients. In addition, tumor-adjacent normal breast tissue was obtained from each patient. The DNA of the tissue cells was extracted and analyzed for complex I mutations using a PCR sequencing method. Our results show 94 mtDNA complex I variants in tumor tissues. A10398G was the most prevalent polymorphism and strongly correlated with Her2 receptor in tumor tissue samples. Mitochondrial DNA (mtDNA) mutations have been widely linked to the etiology of numerous disorders. The mtDNA mutations screening on A10398G along with other mutations might provide insight on the role of mitochondrial mutations in breast cancer. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Jahani MM, et al.. "An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor." Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, vol. 31, no. 1, 2020, pp. 11-16.
APA	Jahani MM, Azimi Meibody A, Karimi T, Banoei MM, Houshmand M (2020). An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor. Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, 31(1), 11-16.
Chicago	Jahani MM, Azimi Meibody A, Karimi T, Banoei MM, Houshmand M. "An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor." Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis 31, no. 1 (2020): 11-16.
Harvard	Jahani MM et al. (2020) 'An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor', Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis, 31(1), pp. 11-16.
Vancouver	Jahani MM, Azimi Meibody A, Karimi T, Banoei MM, Houshmand M. An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor. Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis. 2020;31(1):11-16.
BibTex	@article{ author = {Jahani MM and Azimi Meibody A and Karimi T and Banoei MM and Houshmand M}, title = {An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor}, journal = {Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis}, volume = {31}, number = {1}, pages = {11-16}, year = {2020} }
RIS	TY - JOUR AU - Jahani MM AU - Azimi Meibody A AU - Karimi T AU - Banoei MM AU - Houshmand M TI - An A10398g Mitochondrial Dna Alteration Is Related to Increased Risk of Breast Cancer, and Associates With Her2 Positive Receptor JO - Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis VL - 31 IS - 1 SP - 11 EP - 16 PY - 2020 ER -

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