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Serum Lipoprotein (A) in Diabetic Patients With Various Renal Function Not yet on Dialysis Publisher



Baradaran A1 ; Madihi Y2 ; Merrikhi A2 ; Rafieiankopaei M3 ; Nasri H4, 5
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
  4. 4. Dept. of Internal Medicine, Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Pakistan Journal of Medical Sciences Published:2013


Abstract

To examine the association of serum serum lipoprotein(a)[Lp(a)] concentration with various demographic and biochemical indexes of diabetic patients, we conducted a study on type 2 diabetes mellitus(T2D) patients. Patients were under treatment with insulin injection or oral hypoglycemic agents with various creatinine clearances not yet on dialysis. We studied 122 patients, with a mean age of 63 ± 10 years.The duration of diabetes was 7.4 ± 5.8 years. In this cross-sectional study, serum Lp(a), HbA1c, body mass index (BMI) and creatinine clearance were assessed. The mean serum Lp(a) was 22.2 ± 24.7 mg/dL (median: 18.3 mg/dL), and serum Lp(a) levels more than 30 mg/dL was found in 29 (23.8%) patients. A significant inverse correlation of serum Lp(a) with clearance of creatinine was observed. This study suggests that renal function is an independent determinant of serum Lp(a) in diabetic patients.
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