Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc)

Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc) Publisher

Mm Jahani Mohammad MEHDI ; P Mashayekhi PARISA ; Md Omrani Mir DAVOOD ; A Azimi Meibodi AZITA

Source: Advanced Biomedical Research Published:2025

Abstract

This review systematically evaluated the literature on detecting epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) using plasma exosomal DNA by analyzing data from eight studies selected from a comprehensive literature search (PubMed, Embase, Web of Science; 2010-2024). The findings revealed a wide range of EGFR mutation prevalence (10%-26.8%) across studies, with most mutations located in exons 19 and 21. Comparative analysis highlighted the potential of plasma exosomal DNA (exDNA) as a non-invasive alternative to tissue biopsy, although significant heterogeneity in sensitivity and specificity was observed across liquid biopsy methods (including circulating tumor cells and exDNA analyses). This heterogeneity underscores the need for standardization and further validation to optimize the clinical utility of plasma exDNA in detecting EGFR mutations, monitoring treatment response, and identifying resistance mechanisms in NSCLC. © 2025 Elsevier B.V., All rights reserved.

Style	Citing Format
MLA	Mm Jahani Mohammad MEHDI, et al.. "Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc)." Advanced Biomedical Research, vol. 14, no. 1, 2025, pp. -.
APA	Mm Jahani Mohammad MEHDI, P Mashayekhi PARISA, Md Omrani Mir DAVOOD, A Azimi Meibodi AZITA (2025). Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc). Advanced Biomedical Research, 14(1), -.
Chicago	Mm Jahani Mohammad MEHDI, P Mashayekhi PARISA, Md Omrani Mir DAVOOD, A Azimi Meibodi AZITA. "Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc)." Advanced Biomedical Research 14, no. 1 (2025): -.
Harvard	Mm Jahani Mohammad MEHDI et al. (2025) 'Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc)', Advanced Biomedical Research, 14(1), pp. -.
Vancouver	Mm Jahani Mohammad MEHDI, P Mashayekhi PARISA, Md Omrani Mir DAVOOD, A Azimi Meibodi AZITA. Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc). Advanced Biomedical Research. 2025;14(1):-.
BibTex	@article{ author = {Mm Jahani Mohammad MEHDI and P Mashayekhi PARISA and Md Omrani Mir DAVOOD and A Azimi Meibodi AZITA}, title = {Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc)}, journal = {Advanced Biomedical Research}, volume = {14}, number = {1}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Mm Jahani Mohammad MEHDI AU - P Mashayekhi PARISA AU - Md Omrani Mir DAVOOD AU - A Azimi Meibodi AZITA TI - Review of Plasma Exosomal Dna for Detecting Egfr Mutations in Non-Small Cell Lung Cancer (Nsclc) JO - Advanced Biomedical Research VL - 14 IS - 1 SP - EP - PY - 2025 ER -

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