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Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions in Pharmaceutical Compounds Publisher

Summary: A review highlights new methods to create key drug compounds, improving medicine development. #DrugDevelopment #Pharmaceuticals

Emadi R1 ; Bahrami Nekoo A2 ; Molaverdi F3 ; Khorsandi Z5 ; Sheibani R4 ; Sadeghialiabadi H5
Authors

Source: RSC Advances Published:2023


Abstract

C-N cross-coupling bond formation reactions have become valuable approaches to synthesizing anilines and their derivatives, known as important chemical compounds. Recent developments in this field have focused on versatile catalysts, simple operation methods, and green reaction conditions. This review article presents an overview of C-N cross-coupling reactions in pharmaceutical compound synthesis reports. Selected examples of N-arylation reactions of various nitrogen-based compounds and aryl halides are defined for preparing pharmaceutical molecules. © 2023 The Royal Society of Chemistry.
Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions in Pharmaceutical Compounds