Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Estimation of Absorbed Dose of Salivary Glands in Radioiodine Therapy and Its Reduction Using Pilocarpine



Shahbazigahrouei D1 ; Shahi Z1 ; Ziaie K1 ; Khodamoradi E1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Nuclear Medicine Published:2007

Abstract

Introduction: The use of radioactive iodine (131I) has become an important adjunct to the treatment of thyroid cancer and hyperthyroidism. Salivary gland has the ability to concentrate radioactive iodine under normal circumstances. Salivary gland dysfunction and dry mouth are the common side effects of high-dose radioiodine therapy. The purpose of this study was to determine the absorbed dose of salivary glands. Methods: Twenty patients who were divided into two groups of 10 were studied (A group without pilocarpine and the B group received pilocarpine during treatment). The absorbed dose of parotid glands and the submandibular glands of patients was measured using thermoluminescent dosimeter (TLD) at three different times (24 hours, 8 days and 3 months after treatment). The attenuation coefficient of patients and the effects of pilocarpine were also determined. Results: In group A total attenuation coefficient was 0.335, 0.323, and 0.357 for parotid glands and the right and left submandibular glands, respectively. In group B total attenuation coefficient was 0.462, 0.482, and 0.514 for parotid glands and the right and left submandibular glands, respectively. The results also showed the dose decreases to 1 cGy after 3 and 2 half life for A and B group, respectively. Conclusion: The findings showed that the dose decreases to 1 cGy after 3 half life of Iodine therapy. The exponential coefficient attenuation of salivary glands varied 3% to 4%. Pilocarpine appears to be effective in increasing excretion of radioactive iodine and enhancing coefficient attenuation (up to 1.5 to 2 times).
Related Docs
View other Related Docs
1. Assessment of Patients' and Radiation Worker's Doses in Shahid Chamran Hospital, Isfahan, Iran, and Comparison With Permitted Doses; [اصفهان و مقایسه با دزهای مجازارزیابی دز دریافتی بیماران و پرتوکاران در مرکز تشخیصی و درمانی پزشکی هستهای بیمارستان چمران], Journal of Isfahan Medical School (2024)
2. Dosimetry Evaluation of Salivary Glands in 3D Conformal Radiotherapy and Intensity Modulated Radiotherapy in Oral Tongue Cancer, Koomesh (2020)
3. Determination of Absorbed Dose of Organs (Thyroid, Sternum, Cervical Vertebra) in Thyroid Cancer Patients Following Radioiodine Therapy, Iranian Journal of Nuclear Medicine (2009)
4. Evaluation of Relationship Between Exposure Parameters and Maxillofacial Bone Quality With Salivary Glands Absorbed Dose in Cone Beam Computed Tomography Imaging, Journal of Contemporary Dental Practice (2018)
5. The Effect of Selenium Supplementation on Sonographic Findings of Salivary Glands in Papillary Thyroid Cancer (Ptc) Patients Treated With Radioactive Iodine: Study Protocol for a Double-Blind, Randomized, Placebo-Controlled Clinical Trial, Trials (2023)
6. Determination of Organ Doses in Radioiodine Therapy Using Medical Internal Radiation Dosimetry (Mird) Method, Iranian Journal of Radiation Research (2011)
7. Effects of Early Liothyronine Consumption After Radioiodine Therapy on Accumulated Dose and Exposure Rate in Patients With Thyroid Carcinoma, Iranian Journal of Nuclear Medicine (2008)
8. Evaluation of Radiation-Induced Cancer Risk to Patients Undergoing Intra-Oral and Panoramic Dental Radiographies Using Experimental Measurements and Monte Carlo Calculations, International Journal of Radiation Research (2017)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (7)
Masoud Moslehi (6)
Other Related Docs
9. Radioactive Discharge From Patients With Thyroid Cancer Under 131L Treatment and Its Safe Disposal to the Public Sewer System, Wspolczesna Onkologia (2005)
10. Investigation of the Absorbed Dose and Estimation of the Risk of Secondary Thyroid Cancer in Whole-Brain Radiotherapy, Journal of Isfahan Medical School (2017)
11. Contribution of Ultrasound Examination in the Detection of Neck Recurrence in Low-Risk Differentiated Thyroid Carcinoma Patients at First Follow-Up Visits, Nuclear Medicine Review (2014)
12. Thiocyanate Status Does Not Play a Role in the Etiology of Residual Goiter in School Children of Isfahan, Iran, World Journal of Pediatrics (2010)
13. Evaluation of Risk of Secondary Thyroid Cancer Caused by Neutron Dose Equivalent From Brain Tumor 3D-Conformal Radiation Therapy (3D-Crt), Journal of Isfahan Medical School (2020)
14. Effect of Administrated Activity, Admission Number and Tsh Level on Radiation Retention Curve of Patients Taking Iodine-131 Therapy for Differentiated Thyroid Carcinoma: Looking Beyond Established Regulations, Iranian Journal of Nuclear Medicine (2018)
15. Comparison of 3D Conformal and Intensity Modulated Radiotherapy in Early Stage Oral Tongue Cancer: Dosimetric and Radiobiological Evaluation, International Journal of Radiation Research (2020)
16. Estimation of the Thyroid Secondary Cancer Risk on the Patient of Standard Breast External Beam Radiotherapy, Journal of Medical Signals and Sensors (2018)
17. Urinary Iodine Excretion After Using Povidone Iodine or Chlorhexidine Gluconate for Topical Disinfectant in Patients Undergoing Thyroidectomy Due to Thyroid Carcinoma: When to Do Radio Active Iodine Therapy?, Journal of Research in Medical Sciences (2023)
18. Comparison of the Absorbed Doses of Eyes, Thyroid and Parotid Glands in Dental Cone Beam Computed Tomography (Cbct) and Panoramic Examinations Using Cranex® 3D, Journal of Isfahan Medical School (2016)
19. Estimation of Absorbed Dose of the Thyroid Gland in Patients Undergoing 64-Slice Head Computed Tomography and Comparison the Results With Impact Software and Computed Tomography Scan Dose Index, Journal of Medical Signals and Sensors (2019)
20. The Effect of Neck Physical Examination and Signing Thyroid Nodules by Lead Marker on 99Mtco4 Thyroid Scan Results, Journal of Isfahan Medical School (2014)
21. The Impact of Acute Hypothyroidism on Lipid Levels in Athyreotic Patients, Journal of Research in Medical Sciences (2012)
22. Normal Values of Thyroid Gland in Isfahan, an Iodine Replete Area, Journal of Research in Medical Sciences (2008)
23. The Relationship Between Occupational Radiation Exposure and Thyroid Nodules, Journal of Research in Medical Sciences (2012)
24. Investigating the Out-Of-Field Doses and Estimating the Risk of Secondary Thyroid Cancer in High-Grade Gliomas Radiation Therapy With Modulated Intensity and 3D-Conformal: A Phantom Study, International Journal of Radiation Research (2021)
25. Comparison of Three Methods of Calculation, Experimental and Monte Carlo Simulation in Investigation of Organ Doses (Thyroid, Sternum, Cervical Vertebra) in Radioiodine Therapy, Journal of Medical Signals and Sensors (2012)