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In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared With Those of Five Antifungal Drugs Against Melanized Fungi and Relatives Publisher Pubmed



Shokoohi GR1 ; Badali H2 ; Mirhendi H3 ; Ansari S4 ; Rezaeimatehkolaei A5 ; Ahmadi B6 ; Vaezi A2, 7 ; Alshahni MM8 ; Makimura K8
Authors
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Authors Affiliations
  1. 1. Department of Medical Parasitology and Mycology, School of Public Health, National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Microbiology and Parasitology, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  7. 7. Student Research Committee Center, Mazandaran University of Medical Sciences, Sari, Iran
  8. 8. Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan

Source: Antimicrobial Agents and Chemotherapy Published:2017


Abstract

The in vitro activities of novel azoles compared to those of five antifungal drugs against clinical (n 28) and environmental (n 102) isolates of black mold and melanized yeast were determined. Luliconazole and lanoconazole had the lowest geometric mean MICs, followed by efinaconazole, against tested isolates compared to the other drugs. Therefore, it appears that these new imidazole and triazole drugs are promising candidates for the treatment of infections due to melanized fungi and their relatives. Copyright © 2017 American Society for Microbiology. All Rights Reserved.
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