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Involvement of Single Nucleotide Polymorphisms in Acute Lymphoblastic Leukemia Susceptibility Publisher



Hamzei B1 ; Sheidaeian T2 ; Bahadorzehi N1 ; Sheibani P2 ; Akbari M2 ; Akbari S2 ; Gholizade S2 ; Tabatabae MS2 ; Fattahi Dolatabadi N3 ; Kianpour F4 ; Heidarpour M5 ; Houshmand M6 ; Zamani A3 ; Tabatabaeian H7, 8
Authors
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Authors Affiliations
  1. 1. Department of Cell and Molecular Biology, High Institute Nurdanesh Meymeh, Meymeh, Isfahan, Iran
  2. 2. Department of Genetics, High Institute Nurdanesh Meymeh, Meymeh, Isfahan, Iran
  3. 3. Gene Raz Bu Ali, Genetic and Biotechnology Academy, Isfahan, Iran
  4. 4. Department of Flow Cytometry, Seyed Shohada Medical Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Pathology, Isfahan University of Medical Sciences, Iran
  6. 6. Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Iran
  7. 7. Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
  8. 8. Anahid Cancer Clinic, Isfahan Healthcare City, Isfahan, Iran

Source: Gene Reports Published:2020


Abstract

Acute lymphoblastic leukemia (ALL) is an overgrowth of lymphoid progenitor cells and accounts for the highest common type of childhood cancer. Early detection of ALL could significantly improve the treatment and thereby survival of the patients. Single Nucleotide Polymorphisms (SNPs) have been emerging as effective diagnostic biomarkers in cancer. However, little is known about the association between the SNPs and the risk of ALL. In this study, we genotyped ALL patients and controls for eight SNPs, using the Tetra-primer ARMS PCR method. The results showed there were significant associations between the rs1333048, rs2070672, rs2279744, rs3733890, rs11549465 and the risk of ALL cancer. The findings may have diagnostic implications for early detection of ALL. © 2020 Elsevier Inc.
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