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The Long-Term and Post-Prandial Effects of Berry Consumption on Endothelial Dysfunction in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials Publisher



Talebi S1 ; Shirani M1 ; Shokrimashhadi N2 ; Sadeghi O3 ; Karav S4 ; Bagherniya M3, 5 ; Sahebkar A6, 7, 8
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale, Turkey
  5. 5. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
  7. 7. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Source: International Journal of Food Sciences and Nutrition Published:2025


Abstract

This systematic review and meta-analysis evaluated the long-term and post-prandial effects of berry consumption on endothelial dysfunction (ED) in adults. To identify relevant randomised controlled trials (RCTs), a systematic search was run and studies that examined the effects of berries consumption on ED markers were included. A total of 45 RCTs were included, focusing on markers such as flow-mediated dilation (FMD), pulse wave velocity (PWV), augmentation index (AIx), reactive hyperaemia index (RHI) and total peripheral resistance (TPR). The meta-analysis revealed that long-term berry consumption significantly increased FMD and decreased PWV. However, no significant effects were found for AIx, RHI or TPR. In post-prandial studies, berry consumption also improved FMD, but had no significant impact on PWV, AIx or RHI. Overall, berries were found to benefit endothelial function, particularly in improving FMD, though the effects on other cardiovascular markers were less consistent. Factors like trial design and berry type influenced outcomes. © 2025 Taylor & Francis Group, LLC.
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