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The Association Between Statin Use and Non-Hodgkin Lymphoma; a Systematic Review and Meta-Analysis Publisher



Ghorbani Doshantapeh A1 ; Nouralishahi A2 ; Cheraghalian A3 ; Asgari N4 ; Bagheri Shahzadeh Aliakbari R5 ; Zaman Samghabadi N6 ; Assarroudi M7 ; Zaremoghadam E8, 9 ; Pakdaman Kolour SS10
Authors
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Authors Affiliations
  1. 1. Department of Hematology-Medical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Sub-Department of Operations and Analytics, Department of Management, Faculty of Environment, Science and Economy, University of Exeter, Exeter, United Kingdom
  3. 3. General Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. College of Applied and Natural Sciences, Louisiana Tech University, Ruston, LA, United States
  6. 6. Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Department of Nursing, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
  8. 8. Department of Internal Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
  9. 9. Guissu Research Corporation, Bandar Abbas, Iran
  10. 10. Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Source: Journal of Nephropathology Published:2024


Abstract

Introduction: Statins reduce the cancer risk; however, non-Hodgkin lymphoma (NHL) evidence remains controversial. Therefore, we aimed to evaluate the relationship between statin consumption and NHL risk using a systematic review and meta-analysis. Materials and Methods: In this systematic review and meta-analysis, international databases, including Scopus, PubMed, Web of Science, Cochrane, and Google Scholar search engines, were searched without a time limit up to September 21, 2023. Data analysis was performed using STATA 14 software, and the significance level was considered P<0.05. Results: The results of combining 13 studies (9 case-control studies and 4 cohort studies) with a total sample size of 1 142 740 subjects showed that statin consumption could reduce NHL risk by 22% (RR: 0.78; 95% CI: 0.69, 0.88). Statin consumption in cohort studies reduced NHL risk by 14% (RR: 0.86; 95% CI: 0.77, 0.95), but in case-control studies, it reduced NHL risk by 26% (RR: 0.74; 95% CI: 0.62, 0.90). Furthermore, statin consumption reduced diffuse large B-cell lymphoma risk by 24% (RR: 0.76; 95% CI: 0.67, 0.87) and marginal zone risk by 26% (RR: 0.74; 95% CI: 0.59, 0.93). However, it did not affect reducing the risk of chronic lymphocytic leukemia/small lymphocytic lymphoma (RR: 0.94; 95% CI: 0.85, 1.05), follicular (RR: 0.96; 95% CI: 0.83, 1.10), plasma cell neoplasms (RR: 0.97; 95% CI: 0.70, 1.33), T cell lymphoma (RR: 0.81; 95% CI: 0.55, 1.19) and B cell lymphoma (RR: 0.94; 95% CI: 0.44, 2.01). Conclusion: Statin consumption significantly reduced the risk of NHL, diffuse large B-cell lymphoma, and marginal zone but did not affect other NHL types. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (CRD42023469126) and Research Registry (UIN: reviewregistry1732) website. © 2024 The Author(s).
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