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Correlations Between Single Nucleotide Polymorphisms in Obsessive-Compulsive Disorder With the Clinical Features or Response to Therapy Publisher Pubmed



Beheshti M1 ; Rabiei N2 ; Taghizadieh M3 ; Eskandari P4 ; Mollazadeh S5 ; Dadgostar E6, 7 ; Hamblin MR8 ; Salmaninejad A9, 10 ; Emadi R11 ; Mohammadi AH12 ; Mirazei H12
Authors
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Authors Affiliations
  1. 1. Pathophysiology Laboratory, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Pathology, School of Medicine, Center for Women's Health Research Zahra, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Biology, School of Basic Sciences, University of Guilan, Rasht, Iran
  5. 5. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
  6. 6. Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa
  9. 9. Regenerative Medicine, Organ Procurement and Transplantation Multi Disciplinary Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  10. 10. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  11. 11. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  12. 12. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Journal of Psychiatric Research Published:2023


Abstract

Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder, in which the patient endures intrusive thoughts or is compelled to perform repetitive or ritualized actions. Many cases of OCD are considered to be familial or heritable in nature. It has been shown that a variety of internal and external risk factors are involved in the pathogenesis of OCD. Among the internal factors, genetic modifications play a critical role in the pathophysiological process. Despite many investigations performed to determine the candidate genes, the precise genetic factors involved in the disease remain largely undetermined. The present review summarizes the single nucleotide polymorphisms that have been proposed to be associated with OCD symptoms, early onset disease, neuroimaging results, and response to therapy. This information could help us to draw connections between genetics and OCD symptoms, better characterize OCD in individual patients, understand OCD prognosis, and design more targeted personalized treatment approaches. © 2022 Elsevier Ltd
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