Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Preventive Role of Endothelin Antagonist on Kidney Ischemia: Reperfusion Injury in Male and Female Rats Publisher



Afyouni NE1 ; Halili H1 ; Moslemi F1 ; Nematbakhsh M1, 2 ; Talebi A3 ; Shirdavani S1 ; Maleki M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Preventive Medicine Published:2015


Abstract

Background: Renal ischemia/reperfusion injury (RIRI) is the most common cause of acute kidney injury. We tested the protective role of endothelin‑1 receptor blocker; bosentan (BOS) in animal model of RIRI in two different genders. Methods: Male and female Wistar rats were assigned as sham operated (sham), control group (ischemia), and case group (ischemia + BOS) treated with BOS (50 mg/kg) 2 h before bilateral kidney ischemia induced by clamping renal vessels for 45 min followed by 24 h of renal reperfusion. Results: The RIRI significantly increased the serum levels of blood urea nitrogen and creatinine in both genders (P < 0.05). These values were significantly decreased by BOS in both genders. In male rats, the serum levels of malondialdehyde in the ischemia + BOS group were decreased significantly when compared with ischemia group (P < 0.05). Conclusions: BOS can be used in both genders to attenuate kidney ischemia injury possibly due to its effect in the renal vascular system. © 2015 Afyouni NE.
Related Docs
View other Related Docs
1. Preventive Role of Estradiol on Kidney Injury Induced by Renal Ischemia-Reperfusion in Male and Female Rats, International Journal of Preventive Medicine (2015)
2. Time Course of Renal Ischemia/Reperfusion and Distance Organ: Lung Dysfunction in Male and Female Rats, Physiology and Pharmacology (Iran) (2022)
3. Testosterone and Zinc Supplementations on Renal Ischemia-Reperfusion Injury in Orchiectomized Rats, International Journal of Preventive Medicine (2019)
4. Gender Difference in Renal Blood Flow Response to Angiotensin Ii Administration After Ischemia/Reperfusion in Rats: The Role of At2 Receptor, Advances in Pharmacological Sciences (2016)
5. The Effects of Estrogen on Passive Avoidance Memory Impairment Induced by Acute Kidney Injury in Ovariectomized Rats, Journal of Isfahan Medical School (2019)
6. The Effect of At2 and Mas Receptors Antagonists on Renal Hemodynamic and Excretory Disorders Induced by Ischemia/Reperfusion in Male and Female Rats, Physiology and Pharmacology (Iran) (2018)
7. Mas Receptor Blockade Promotes Renal Vascular Response to Ang Ii After Partial Kidney Ischemia/Reperfusion in a Two-Kidney-One-Clip Hypertensive Rats Model, International Journal of Nephrology (2021)
8. N-Acetylcysteine Prevents Kidney and Lung Disturbances in Renal Ischemia/ Reperfusion Injury in Rat, International Journal of Preventive Medicine (2013)
Experts (# of related papers)
View all Related Experts
Mehdi Nematbakhsh (64)
Ardeshir Talebi (20)
Other Related Docs
9. Sodium Hydrogen Sulfide May Not Protect the Kidney Against Ischemia/Reperfusion Damage in Male and Female Rats, Research in Pharmaceutical Sciences (2023)
10. Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats, Scientifica (2016)
11. Role of Endothelin Receptor Antagonist; Bosentan in Cisplatininduced Nephrotoxicity in Ovariectomized Estradiol Treated Rats, Journal of Nephropathology (2015)
12. The Protective Effect of Γ‑Aminobutyric Acid on Kidney Injury Induced by Renal Ischemia‑Reperfusion in Ovariectomized Estradiol‑Treated Rats, International Journal of Preventive Medicine (2016)
13. Effects of Vasodepressor Vs. Vasopressor Arms of Renin Angiotensin System on Renal Hemodynamic Regulation in Renal Ischemia-Reperfusion Injury; Sex Difference, Journal of Isfahan Medical School (2022)
14. Gender Differences in Response to Vitamin E and C in Gentamicin Induced Nephrotoxicity in Wistar Rats, Journal of Nephropathology (2017)
15. Protective Role of Recombinant Human Erythropoietin in Kidney and Lung Injury Following Renal Bilateral Ischemia-Reperfusion in Rat Model, International Journal of Preventive Medicine (2013)
16. Evaluating the Effect of Remote Ischemic Preconditioning on Kidney Ischemia-Reperfusion Injury, Journal of Research in Medical Sciences (2020)
17. Zinc Supplementation and Ischemia Pre-Conditioning in Renal Ischemia/ Reperfusion Injury, Malaysian Journal of Medical Sciences (2019)
18. Nitric Oxide Metabolite Changes in Gentamicin-Induced Nephrotoxicity; the Effects of Antioxidant Vitamins, Journal of Renal Injury Prevention (2018)
19. How Effective Are Alprostadil and Hydrocortisone on Reperfusion Injury in Kidney After Distant Organ Ischemia?, Journal of Research in Medical Sciences (2013)
20. Effect of Testosterone on Cisplatin-Induced Nephrotoxicity in Surgically Castrated Rats, Nephro-Urology Monthly (2014)
21. Mas Receptor Antagonist (A799) Alters the Renal Hemodynamics Responses to Angiotensin Ii Administration After Renal Moderate Ischemia/Reperfusion in Rats: Gender Related Differences, Research in Pharmaceutical Sciences (2019)
22. Effect of L‑Arginine and L‑Name on Kidney Tissue Damage in Rats After 24 H of Bilateral Ureteral Obstruction, International Journal of Preventive Medicine (2015)
23. Protective Effect of N-Acetylcysteine on Kidney As a Remote Organ After Skeletal Muscle Ischemia-Reperfusionspi; [Efeito Protetor Da N-Acetilcisteina No Rim Como Um Orgao Remoto Musculo Esqueletico Apos Isquemia-Reperfusao], Acta Cirurgica Brasileira (2012)
24. Renal Vascular Responses to Angiotensin Ii Infusion in Two Kidneys-One Clip Hypertensive Rats Under Partial Ischemia/Reperfusion With and Without Ischemia Preconditioning: The Roles of At1r Blockade and Co-Blockades of At1r and Masr, Research in Pharmaceutical Sciences (2023)
25. Angiotensin 1-7 Administration Increases Renal Blood Flow in the Absence of Bradykinin B2 Receptor in Ovariectomized Estradiol Treated Rats: The Role of Mas Receptor, Acta Medica Iranica (2019)
26. Tramadol Alleviates Myocardial Injury Induced by Acute Hindlimb Ischemia Reperfusion in Rats; [Tramadol Atenua Lesoes Miocardicas Induzidas Pela Reperfusao Pos- Isquemica Aguda De Membros Posteriores Em Ratos], Arquivos Brasileiros de Cardiologia (2015)
27. Role of Mas Receptor Antagonist (A779) on Pressure Diuresis and Natriuresis and Renal Blood Flow in the Absence of Angiotensin Ii Receptors Type 1 and 2 in Female and Male Rats, Journal of Physiology and Pharmacology (2014)
28. Role of Mas Receptor in Renal Blood Flow Response to Angiotensin (1-7) in Male and Female Rats, General Physiology and Biophysics (2014)
29. The Role of Mas Receptor on Renal Hemodynamic Responses to Angiotensin Ii Administration in Chronic Renal Sympathectomized Male and Female Rats, Research in Pharmaceutical Sciences (2023)
30. High-Salt Intake During Pregnancy May Influence the Outcome of Renal Ischemia/Reperfusion in in Adult Offspring, Journal of Renal Injury Prevention (2018)
31. Protective Role of Silymarin and Deferoxamine Against Iron Dextran-Induced Renal Iron Deposition in Male Rats, International Journal of Preventive Medicine (2013)
32. Bilirubin Improves Renal Function by Reversing the Endoplasmic Reticulum Stress and Inflammation in the Kidneys of Type 2 Diabetic Rats Fed High-Fat Diet, Chemico-Biological Interactions (2023)
33. Renal Vascular Response to Angiotensin 1-7 in Rats: The Role of Mas Receptor, Research in Pharmaceutical Sciences (2018)
34. Role of Exogenous Nitric Oxide Donor in Treatment of Decompensated Hemorrhagic Shock in Normotensive and Hypertensive Rats, Journal of Biomedicine and Biotechnology (2012)
35. Sex Differences in the Renal Vascular Responses of At1and Mas Receptors in Two-Kidney-One-Clip Hypertension, International Journal of Hypertension (2021)
36. Renal Blood Flow and Vascular Resistance Responses to Angiotensin Ii in Irreversible and Reversible Unilateral Ureteral Obstruction Rats; the Role of Angiotensin Ii Type 1 and 2 Receptors, Journal of Nephropathology (2018)
37. The Role of Angiotensin Ii Receptor 1 (At1) Blockade in Cisplatin-Induced Nephrotoxicity in Rats: Gender-Related Differences, Renal Failure (2012)
38. Dextrose Hydration May Promote Cisplatin-Induced Nephrotoxicity in Rats: Gender-Related Difference, Indonesian Biomedical Journal (2019)
39. Carvacrol Exerts Nephroprotective Effect in Rat Model of Diclofenac-Induced Renal Injury Through Regulation of Oxidative Stress and Suppression of Inflammatory Response, Heliyon (2021)
40. Gender Difference in Cisplatin-Induced Nephrotoxicity in a Rat Model: Greater Intensity of Damage in Male Than Female, Nephro-Urology Monthly (2013)
41. Proteomics to Metabolomics: A New Insight Into the Pathogenesis of Hypertensive Nephropathy, Kidney and Blood Pressure Research (2023)
42. Gender Differences in Pressure-Natriuresis and Renal Autoregulation: Role of the Angiotensin Type 2 Receptor, Hypertension (2011)
43. The Denervation or Activation of Renal Sympathetic Nerve and Renal Blood Flow, Journal of Research in Medical Sciences (2023)
44. N-Acetylcysteine and Cisplatin-Induced Nephrotoxicity: Is It a Suitable Antioxidant Supplementation to Prevent Nephrotoxicity in Male or Female Rats?, Journal of Isfahan Medical School (2013)
45. Angiotensin 1-7 Administration Alters Baroreflex Sensitivity and Renal Function in Sympathectomized Rats, Journal of Nephropathology (2018)
46. Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 After Bradykinin Administration in Ovariectomized Estradiol-Treated Rats, Advances in Pharmacological Sciences (2015)
47. Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant Against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model, International Journal of Nephrology (2012)
48. Erythropoietin Ameliorates Genetamicin-Induced Renal Toxicity: A Biochemical and Histopathological Study, Journal of Nephropathology (2012)
49. Hemodynamic Responses and Serum Nitrite Concentration During Uncontrolled Hemorrhagic Shock in Normotensive and Hypertensive Rats, Biomedical Papers (2012)
50. Protective Effect of Gastric Distension Preconditioning on Renal Ischemia/Reperfusion Injury in Rats, Indian Journal of Nephrology (2018)