Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Intralesional Triamcinolone Versus Combination of Intralesional Triamcinolone With Co2 Fraxel Laser in Treatment of Patients With Hypertrophic Scars



Nilforoushzadeh MA1 ; Siadat AH2 ; Haftbaradaran E3 ; Shahbazi F4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran and Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Skin Disease and Leishmaniasis Research Center and Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Skin Disease and Leishmaniasis Research Center and Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2013

Abstract

Background: Hypertrophic scars are benign growths of dermal collagen that can couse physical and psychological (cosmetic) problems for patients. Methods: A total of 36 patients were studied and randomly divided into 2 groups; 18 patients were treared with intralesional injection of triamcinolone and 18 other patients were treated with combination of fractional laser and intralesional injection of triamcinolone. The cure rate of the lesions in pain, induration, pruritus, erythema and burning were assessed and compared between the groups. Findings: In group with intralesional injection of triamcinolone, cure rate was 39% in erythema, 45% in pain, 100% in burning, 67% in induration and 45% in pruritus. In group with combination of fractional laser and intralesional injection of triamcinolone, cur was 89% in erythema, 67% in pain, 23% in burning, 83% in induration and 72% in pruritus. The differences between the groups were significant in all issues (P < 0.001 for all). Conclusion: This study showed that combination of fractional laser and intralesional injection of triamcinolone has significantly higher cure rate of hypertrophic scars than intralesional injection of triamcinolone alone.
Related Docs
View other Related Docs
1. New Combination of Triamcinolone, 5-Fluorouracil, and Pulsed-Dye Laser for the Treatment of Keloid Andhypertrophic Scars, Journal of Isfahan Medical School (2012)
2. New Combination of Triamcinolone, 5-Fluorouracil, and Pulsed-Dye Laser for Treatment of Keloid and Hypertrophic Scars, Dermatologic Surgery (2006)
3. Intralesional Triamcinolone Alone or in Combination With 5-Fluorouracil for the Treatment of Keloid and Hypertrophic Scars, Clinical and Experimental Dermatology (2009)
4. Comparative Study of the Efficacy of Co2 and Fraxel Lasers in Treatment of Cutaneous Leishmaniasis Scars, Journal of Isfahan Medical School (2014)
5. A Comparison Between the Effects of Glucantime, Topical Trichloroacetic Acid 50% Plus Glucantime, and Fractional Laser Plus Glucantime on Cutaneous Leishmaniasis Lesions, Journal of Isfahan Medical School (2013)
6. Comparison of Q-Switched 1064-Nm Nd: Yag Laser and Fractional Co2 Laser Efficacies on Improvement of Atrophic Facial Acne Scar, Journal of Research in Medical Sciences (2011)
7. A Comparative Study on the Usefulness of Fractional Co 2 and Fractional Er:Yag in Acne Scars: A Split-Face Trial, Advanced Biomedical Research (2023)
8. Evaluation of the Efficacy of Piroxicam Gel in the Control of Pain and Erythema Caused by Fractional Co2 Laser Compared With Lubricant Gel, Journal of Isfahan Medical School (2011)
Experts (# of related papers)
View all Related Experts
Ali Asilian (12)
Gita Faghihi (9)
Other Related Docs
9. Low Level Laser Therapy for the Treatment of Chronic Wound: Clinical Considerations, Biomedical and Pharmacology Journal (2015)
10. Efficacy of Fractionated Microneedle Radiofrequency With and Without Adding Subcision for the Treatment of Atrophic Facial Acne Scars: A Randomized Split-Face Clinical Study, Journal of Cosmetic Dermatology (2017)
11. Comparison of Two Methods of Subcision Nokor and Blunt Blade in Acne Scars Treatment, Journal of Cosmetic Dermatology (2019)
12. The Comparison Between Trichloroacetic Acid 50% and Co2 Laser in the Treatment of Cutaneous Leishmaniasis Scar, Indian Journal of Dermatology (2011)
13. Fractional Co2 Laser As an Effective Modality in Treatment of Striae Alba in Skin Types Iii and Iv, Journal of Research in Medical Sciences (2012)
14. Comparison of Clinical Indices and Therapeutic Effect of a Mucoadhesive System Containing Melissa 1% and Triamcinolone 0.1% on Lichenoid Reactions, Dental Research Journal (2022)
15. Evaluation of the Effects of Low Level Laser Therapy on the Healing Process After Skin Graft Surgery in Burned Patients (A Randomized Clinical Trial), Journal of Lasers in Medical Sciences (2018)
16. Efficacy of Autologous Platelet-Rich Plasma Combined With Fractional Ablative Carbon Dioxide Resurfacing Laser in Treatment of Facial Atrophic Acne Scars: A Split-Face Randomized Clinical Trial, Indian Journal of Dermatology, Venereology and Leprology (2016)
17. Fractional Co2 Laser As an Effective Modality in Treatment of Striae Alba in Skin Types Iii and Iv, Journal of Isfahan Medical School (2014)
18. Comparison of Fractional Carbon Dioxide Laser Alone and in Combination With Subcision in Improving Atrophic Acne Scars, Journal of Isfahan Medical School (2013)
19. The Effect of Homograft Fillers on the Correction of Atrophic Scars, Journal of Isfahan Medical School (2017)
20. Combination of Continuous Wave Co2 Laser and Topical Application of Trichloroacetic Acid 50% Vs Co2 Laser Alone the Treatment of Cutaneous Leishmaniasis (A Case Series of 6 Patients), Journal of Cosmetic Dermatology (2020)
21. Comparison of the Effect of Topical Triamcinolone 0.1% Cream With Sulfur 2.0% Cream in the Treatment of Patients With Hand Eczema: A Randomized Controlled Trial, Journal of Cosmetic Dermatology (2024)
22. Bevacizumab As Adjuvant Therapy in the Treatment of Keloid: A Randomized Clinical Trial, Dermatologic Therapy (2024)
23. Systematic Review and Meta-Analysis of Randomized Clinical Trials Comparing Efficacy, Safety, and Satisfaction Between Ablative and Non-Ablative Lasers in Facial and Hand Rejuvenation/Resurfacing, Lasers in Medical Science (2022)
24. A Comparison Between the Effects of Glucantime, Topical Trichloroacetic Acid 50% Plus Glucantime, and Fractional Carbon Dioxide Laser Plus Glucantime on Cutaneous Leishmaniasis Lesions, Dermatology Research and Practice (2016)
25. Efficacy of Punch Elevation Combined With Fractional Carbon Dioxide Laser Resurfacing in Facial Atrophic Acne Scarring: A Randomized Split-Face Clinical Study, Indian Journal of Dermatology (2015)
26. Comparing the Effects of Conventional Method, Pulse Dye Laser and Erbium Laser for the Treatment of Hypertrophic Scars in Iranian Patients, Journal of Research in Medical Sciences (2007)
27. Comparative Effects of Salvizan Gel (Containing Salvia Officinalis Extract) and Triamcinolone Acetonide Gel on the Duration and Symptoms of Oral Lichenoid Reactions, Dentistry 3000 (2022)
28. Endo-Radiofrequency Subcision for Acne Scars Treatment: A Case Series Study, Journal of Cosmetic Dermatology (2022)
29. Can Subcision With the Cannula Be an Acceptable Alternative Method in Treatment of Acne Scars?, Medical archives (Sarajevo, Bosnia and Herzegovina) (2015)
30. Bleomycin Tattooing As a Promising Therapeutic Modality in Large Keloids and Hypertrophic Scars, Dermatologic Surgery (2006)
31. The Impacts of Low-Level Laser Therapy - a Complementary Treatment in the Management of Side Effects After Implant Surgery, Journal of Lasers in Medical Sciences (2018)
32. Efficacy of Photo Bio-Modulation Therapy for Pain Relief and Soft Tissue Wound Healing After Dental Implant Surgery: A Double-Blind Randomized Clinical Trial, Journal of Photochemistry and Photobiology (2021)
33. Q-Switched Frequency-Doubled Nd:Yag (532 Nm) Laser Versus Trichloroacetic Acid 35% Peeling in the Treatment of Dorsal Hand Solar Lentigo: An Assessor-Blind Split-Hand Randomized Controlled Trial, Journal of Cosmetic Dermatology (2022)
34. Comparison of Therapeutic Effect of Mucoadhesive Nano-Triamcinolone Gel and Conventional Triamcinolone Gel on Oral Lichen Planus, Dental Research Journal (2019)
35. A Double-Blind Randomized Trial on the Effectiveness of Mometasone 0.1% Cream and Hydrocortisone 1% Cream on the Prevention of Acute Radiation Dermatitis in Breast Cancer Patients Following, Middle East Journal of Cancer (2021)
36. The Effect of Sage (Salvizan Gel) Compared to Triamcinolone Acetonide on the Treatment of Recurrent Aphthous Stomatitis: A Double-Blinded Randomized Clinical Trial, BMC Oral Health (2023)
37. Comparing Cannula-Based Subcision With the Common Needle Method: A Clinical Trial, Skin Research and Technology (2020)
38. Fractional Erbium:Yag Laser (2940 Nm) Plus Topical Hydroquinone Compared to Intradermal Tranexamic Acid Plus Topical Hydroquinone for the Treatment of Refractory Melasma: A Randomized Controlled Trial, Journal of Dermatological Treatment (2022)
39. Clinical Outcomes of Low-Level Laser Therapy in Management of Advanced Implant Surgery Complications: A Comparative Clinical Study, Journal of Contemporary Dental Practice (2019)
40. Comparison of Therapeutic Effect of Mucoadhesive Nanotriamcinolone Gel and Conventional Triamcinolone Gel on Recurrent Aphthous Stomatitis; [Comparacao Do Efeito Terapeutico Do Gel Mucoadesivo De Nano-Triancinolona E Do Gel Convencional De Triancinolona Na Estomatite Aftosa Recorrente], Brazilian Dental Science (2019)