Allium Hirtifolium Boiss: Radical Scavenging Property and the Lowering Effects on Blood Fibrinogen and Factor Vii



Asgari S¹ ; Rafieiankopaei M² ; Pourgheysari B² ; Ansarisamani R² ; Deris F² ; Shahinfard N² ; Hojjati MR² ; Salimi M² Show Affiliations
Source: Life Science Journal Published:2012

Abstract

Enhancement of blood fibrinogen or factor VII increases cardiovascular diseases. Allium hirtifolium Boiss (Mosir) has been shown to have cardioprotective effect. This study, therefore, aimed to evaluate the effects of Allium hirtifolium Boiss on factor VII and fibrinogen blood levels. Its radical scavenging property was also measured. Twenty four NewZealand male rabbits were randomly designated into 3 groups of 8 and were fed for 60 days with normal diet, hypercholestrol (1%) diet or hypercholestrol (1%) diet+ Mosir. At the beginning and 60 days after the start of the study, the blood fibrinogen and factor 7 were measured and compared in different groups. The Mosir radical scavenging property was measured using the beta-carotene linoleate method. The blood fibrinogen and factor 7 were higher in hypercholesterolemic group (26.7 ± 329.22 and 17.1 ± 277.7mg/dl) compared to normal diet group (13.7 ± 287.25 and 18.2 ± 230.0 mg / dl, respectively) (P<0.05), at the end of the experiment. The amount of blood fibrinogen and factor 7 were decreased in hypercholesterol+Mosir group (23.9 ± 180.00 and 53.3 ± 237.0 mg / dl) compared to hypercholesterol diet group (P<0.05). radical scavenging activity of Mosir extract was 52.1 ± 3.3%. Mosir may have beneficial effect on heart by decreasing blood fibrinogen and factor 7 as cardiovascular risk factors. These effects of Mosir should be considered carefully in patients with hemostatic disorders.