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A Comparative Study of the Prescription of Memantine and Piracetam in Poststroke Aphasia



Khorvash F1 ; Ghasemi M1 ; Naderi M2 ; Mirmosayyeb O3
Authors
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Authors Affiliations
  1. 1. Isfahan Neuroscience Research Center, Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Isfahan Neurosciences Research Center, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2015

Abstract

Background: Aphasia is an acquired linguistic disease caused by brain injuries mostly in the left hemisphere. The symptoms can contain a vast spectrum of clinical manifestations. Methods: This double-blind randomized clinical trial study observed 70 patients with stroke. Patients’ characteristics and their demographic information registered prior to the intervention. Then, they were divided in two equal groups randomly; one group received piracetam and the other got memantine. Findings: The mean age was 61.6 ± 11.8 and 62.7 ± 11.8 years in memantine and piracetam groups, respectively. Covariance analysis demonstrated more significant improvements in memantine group in all aspects of the study except the fluency of speech. Conclusion: While memantine improve lots of symptoms of aphasia, todays it is less considered by physicians. However, we recommend its prescription in patients with aphasia as a safe and efficient drug. © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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