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The Effect of Cocoa/Dark Chocolate Consumption on Lipid Profile, Glycemia, and Blood Pressure in Diabetic Patients: A Meta-Analysis of Observational Studies Publisher Pubmed



Darand M1 ; Hajizadeh Oghaz M2 ; Hadi A3 ; Atefi M1 ; Amani R1
Authors

Source: Phytotherapy Research Published:2021


Abstract

Due to the increasing rate of cardiovascular disease and related risk factors in the worldin recent decades, the present meta-analysis was performed to investigate the effects ofcocoa/chocolate consumption on lipid profile, glycemia, and blood pressure control in diabetic patients. A systematic search of the databases PubMed, Scopus, Web of Science, and Cochran Library was performed up to July 2020. All randomized controlled trials (RCTs) using cocoa/dark chocolate in diabetic patients were included in the study. The search results were limited to English-language publications. Eight RCTs, including 433 participants, were selected for this meta-analysis. Pooled analysis indicated a significant reduction in low-density lipoprotein cholesterol LDL-c levels (WMD: −15.49 mg/dl; 95% CI: −24.56, −6.42, p =.001) and fasting blood sugar (FBS) concentrations (WMD: −6.88 mg/dl; 95% CI: −13.28, −0.48, p =.03) following cocoa/dark chocolate consumption. The analysis of papers included in current study indicates that the consumption of cocoa/dark chocolate reduced the serum fasting blood glucose (FBS) and LDL cholesterol concentrations. However, further high quality trials are essential for confirming the clinical efficacy of cocoa/dark chocolate consumption on complete metabolic profile. © 2021 John Wiley & Sons Ltd
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