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The Effect of Cocoa/Dark Chocolate Consumption on Lipid Profile, Glycemia, and Blood Pressure in Diabetic Patients: A Meta-Analysis of Observational Studies Publisher Pubmed



Darand M1 ; Hajizadeh Oghaz M2 ; Hadi A3 ; Atefi M1 ; Amani R1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Nutrition and Health Sciences, College of Education and Human Sciences, University of Nebraska-Lincoln, NE, United States
  3. 3. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran, Iran

Source: Phytotherapy Research Published:2021


Abstract

Due to the increasing rate of cardiovascular disease and related risk factors in the worldin recent decades, the present meta-analysis was performed to investigate the effects ofcocoa/chocolate consumption on lipid profile, glycemia, and blood pressure control in diabetic patients. A systematic search of the databases PubMed, Scopus, Web of Science, and Cochran Library was performed up to July 2020. All randomized controlled trials (RCTs) using cocoa/dark chocolate in diabetic patients were included in the study. The search results were limited to English-language publications. Eight RCTs, including 433 participants, were selected for this meta-analysis. Pooled analysis indicated a significant reduction in low-density lipoprotein cholesterol LDL-c levels (WMD: −15.49 mg/dl; 95% CI: −24.56, −6.42, p =.001) and fasting blood sugar (FBS) concentrations (WMD: −6.88 mg/dl; 95% CI: −13.28, −0.48, p =.03) following cocoa/dark chocolate consumption. The analysis of papers included in current study indicates that the consumption of cocoa/dark chocolate reduced the serum fasting blood glucose (FBS) and LDL cholesterol concentrations. However, further high quality trials are essential for confirming the clinical efficacy of cocoa/dark chocolate consumption on complete metabolic profile. © 2021 John Wiley & Sons Ltd
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