Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Relationship Between Programmed Cell Death Receptor-1 Expression in Colon Tumoral Tissue and Clinical and Pathological Characteristics of Patients With Colon Cancer; [ارتباط بیان گیرنده ی مرگ برنامه ریزی شده 1 در بافت تومورال روده ی بزرگ با ویژگی های بالینی و آسیب شناسی بیماران مبتلا به سرطان روده ی بزرگ] Publisher



Mokhtari Z1 ; Rezaei M1 ; Sanei MH2 ; Faghih Z3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Institute for Cancer Research (ICR), School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Journal of Isfahan Medical School Published:2023


Abstract

Background: Activatory or inhibitory immune checkpoints regulate the activity of the immune system. Programmed cell death receptor 1 (PD-1 is an inhibitory immune checkpoint that their overexpression reflects the exhaustion of the immune system. However, it is still unclear how it affects the prognosis of colorectal cancer (CRC). This study aimed to investigate the prognostic value of PD-1 in patients with CRC according to tumor location. Methods: In a cross-sectional study during 2020-2021, a number of 136 patients with history of CRC who underwent surgery at Al-Zahra Hospital in Isfahan between 2013 and 2017 were selected and evaluated retrospectively. Immuno-histochemical staining of tissue samples was performed for PD-1 marker and the expression of this marker was determined in the center and invasive margins of the tumor. Data on survival and date of death of patients were completed through the patient file and confirmed through the civil registry. Findings: High expression of PD-1 in invasive margin was significantly related to lower T stage (T1/2) in left tumors, low M stage (M0) in right tumors, absence of metastasis in right and left tumors, larger tumor size (≥ 5 cm) in right-sided tumors. The expression of this marker in any tumor areas was not significantly related to the survival of the patients. Conclusion: The findings of this study showed that high expression of PD-1 is related to the lower stages of the CRC, but it is not a good indicator for the prognosis of patients with colon cancer. © 2023 Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Tim3 and Pd-1 As a Therapeutic and Prognostic Targets in Colorectal Cancer: Relationship With Sidedness, Clinicopathological Parameters, and Survival, Frontiers in Oncology (2023)
2. A Comprehensive Study on the Prognostic Value and Clinicopathological Significance of Different Immune Checkpoints in Patients With Colorectal Cancer: A Systematic Review and Meta-Analysis, Current Therapeutic Research - Clinical and Experimental (2024)
3. Assessment of Immuno-Histochemical Expression of Mbd1 in Colorectal Adenocarcinoma and Its Correlations With Prognostic Factors, Middle East Journal of Digestive Diseases (2020)
4. Ret Protein Expression in Colorectal Cancer; an Immunohistochemical Assessment, Asian Pacific Journal of Cancer Prevention (2021)
5. Investigating the Effect of Fusobacterium Nucleatum on the Aggressive Behavior of Cancer-Associated Fibroblasts in Colorectal Cancer, Discover Oncology (2024)
6. Immune Checkpoint Inhibition for the Treatment of Cancers: An Update and Critical Review of Ongoing Clinical Trials, Clinical Immunology (2021)
7. Bispecific Antibodies in Colorectal Cancer Therapy: Recent Insights and Emerging Concepts, Immunotherapy (2021)
8. Predictive Value of Tissue Inhibitor of Metalloproteinases-1 and Carcinoembryonic Antigen Plasma Levels in Response to Chemotherapy in Patients With Metastatic Colorectal Cancer, Journal of Research in Medical Sciences (2014)
Experts (# of related papers)
View all Related Experts
Mohammad Hossein Sanei (5)
Marzieh Rezaei (4)
Other Related Docs
9. Analysis of Tslc1 Expression in Colorectal Cancer Specimens by Immunohistochemistry, Journal of Isfahan Medical School (2012)
10. Research Paper: Immune Checkpoint Molecules in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System, Basic and Clinical Neuroscience (2020)
11. Leng8-As1: A Prognostic Biomarker in Colorectal Cancer-Differential Expression and Clinical Implications, Indian Journal of Clinical Biochemistry (2024)
12. Circadian and Immunity Cycle Talk in Cancer Destination: From Biological Aspects to in Silico Analysis, Cancers (2022)
13. Immune Checkpoint Status and Tumor Microenvironment in Vulvar Squamous Cell Carcinoma, Virchows Archiv (2020)
14. Effect of Number of Dissected Lymph Nodes on Prognosis of Patients With Stage Ii and Iii Colorectal Cancer, Exploration of Medicine (2023)
15. Comparative Expression of Breast Cancer 1 Tumor Suppressor Protein in Cancerous and Healthy Colorectal Specimens, Journal of Isfahan Medical School (2016)
16. The Role of Tim-3 in Hepatocellular Carcinoma: A Promising Target for Immunotherapy?, Frontiers in Oncology (2020)
17. Study of P33 Tumor Suppressor Protein Expression in Normal and Cancerous Colorectal Tissues, Journal of Isfahan Medical School (2010)
18. Exploring the Role of Interleukin 11 in Cancer Progression, Patient Survival, and Therapeutic Insights, Molecular Biology Reports (2024)
19. Immunohistochemical Analysis of Mismatch Repair Proteins in Iranian Colorectal Cancer Patients at Risk for Lynch Syndrome, Iranian Journal of Cancer Prevention (2015)
20. Evaluation of Cd133 Expression Rate in Colon Cancers With Immunohistochemistry Method and Its Relationship With Colon Cancer Prognosis, Immunopathologia Persa (2024)
21. An Immunohistochemical Study of Egfr Expression in Colorectal Cancer and Its Correlation With Lymph Nodes Status and Tumor Grade, Journal of Research in Medical Sciences (2012)
22. Comparative Analysis of Apc Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry, Journal of Isfahan Medical School (2012)
23. Pd-1/Pd-L1 Interaction Regulates Bcl2, Ki67, Bax, and Casp3, Altering Proliferation, Survival, and Apoptosis in Acute Myeloid Leukemia, Iranian Journal of Allergy, Asthma and Immunology (2023)
24. Clinicopathological Significance and Prognostic Role of Lag3 + Tumor-Infiltrating Lymphocytes in Colorectal Cancer; Relationship With Sidedness, Cancer Cell International (2023)
25. The Decrease in Nkg2d+ Natural Killer Cells in Peripheral Blood of Patients With Metastatic Colorectal Cancer, Bratislava Medical Journal (2015)
26. Association of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio With Tumoral Differentiation in Colorectal Cancer, Gene Reports (2022)
27. The Significance of Clinicopathological Aspects of Tumor for the Detection of Liver Micrometastasis in Patients With Colorectal Cancer, Journal of Research in Medical Sciences (2014)
28. Micrometastasis in Colorectal Cancer: Does It Affect Staging?, ANZ Journal of Surgery (2018)
29. Comparison of Laboratory Methods for the Clinical Follow up of Checkpoint Blockade Therapies in Leukemia: Current Status and Challenges Ahead, Frontiers in Oncology (2022)
30. Decline in Peripheral Blood Nkg2d+Cd3+Cd56+ Nkt Cells in Metastatic Colorectal Cancer Patients, Bratislava Medical Journal (2018)
31. Nivolumab Plus Ipilimumab Combination Therapy in Cancer: Current Evidence to Date, International Immunopharmacology (2023)
32. Investigation of Clinicopathological Parameters in Emergency Colorectal Cancer Surgery: A Study of 67 Patients, Archives of Medical Science (2017)
33. The Relationship Between Involved Lymph Nodes, Metastatic Nest Diameters and Prognosis in Colorectal Cancer, Journal of Gastrointestinal and Liver Diseases (2008)
34. Expression and Prognostic Significance of Stem Cell Marker Cd133 in Survival Rate of Patients With Colon Cancer, Oncology and Therapy (2022)
35. Analysing Glycolysis-Related Genes Reveals the Prognostic and Diagnostic Relevance of Ier3 and Agrn in Colorectal Cancer, Genes and Genomics (2025)