Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique

Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique Publisher Pubmed

Varshosaz J¹ ; Tavakoli N¹ ; Serri A¹

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1. Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Pharmaceutical Development and Technology Published:2009

Abstract

The objective of this study was to develop piroxicam enteric coated pellets using nonpareil seeds by powder layering technique to minimize its gastrointestinal adverse effects. Inert seeds were prepared by incorporating sugar, Avicel PH 101 and lactose. The obtained cores were then treated by PVP 10 w/v % solution using centrifugal granulator (CF-granulator) and then coated with micronized piroxicam using HPMC solution (8 w/v %) as binder. The piroxicam pellets were finally coated with different polymers (Eudragit L30D-55, Eudragit L100, Eudragit NE30D, Acryleze, or mixture of Eudragits L30D-55 and NE30D) and plasticizers (triethyl citrate and polyethylene glycol 6000). Results showed that Eudragit L30D-55 with 3% weight gain accompanied with TEC produced suitable enteric coated pellets. © 2009 Informa UK Ltd.

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Style	Citing Format
MLA	Varshosaz J, Tavakoli N, Serri A. "Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique." Pharmaceutical Development and Technology, vol. 14, no. 3, 2009, pp. 305-311.
APA	Varshosaz J, Tavakoli N, Serri A (2009). Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique. Pharmaceutical Development and Technology, 14(3), 305-311.
Chicago	Varshosaz J, Tavakoli N, Serri A. "Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique." Pharmaceutical Development and Technology 14, no. 3 (2009): 305-311.
Harvard	Varshosaz J, Tavakoli N, Serri A (2009) 'Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique', Pharmaceutical Development and Technology, 14(3), pp. 305-311.
Vancouver	Varshosaz J, Tavakoli N, Serri A. Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique. Pharmaceutical Development and Technology. 2009;14(3):305-311.
BibTex	@article{ author = {Varshosaz J and Tavakoli N and Serri A}, title = {Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique}, journal = {Pharmaceutical Development and Technology}, volume = {14}, number = {3}, pages = {305-311}, year = {2009} }
RIS	TY - JOUR AU - Varshosaz J AU - Tavakoli N AU - Serri A TI - Preparation and in Vitro Characterization of Piroxicam Enteric Coated Pellets Using Powder Layering Technique JO - Pharmaceutical Development and Technology VL - 14 IS - 3 SP - 305 EP - 311 PY - 2009 ER -

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