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Cohort Profile: A Collaborative Multicentre Study of Retinal Optical Coherence Tomography in 539 Patients With Neuromyelitis Optica Spectrum Disorders (Croctino) Publisher Pubmed



Specovius S1, 2 ; Zimmermann HG1, 2 ; Oertel FC1, 2 ; Chien C1, 2 ; Bereuter C1, 2 ; Cook LJ3 ; Lana Peixoto MA4 ; Fontenelle MA4 ; Kim HJ5 ; Hyun JW5 ; Jung SK6 ; Palace J7 ; Rocafernandez A8 ; Diaz AR7 Show All Authors
Authors
  1. Specovius S1, 2
  2. Zimmermann HG1, 2
  3. Oertel FC1, 2
  4. Chien C1, 2
  5. Bereuter C1, 2
  6. Cook LJ3
  7. Lana Peixoto MA4
  8. Fontenelle MA4
  9. Kim HJ5
  10. Hyun JW5
  11. Jung SK6
  12. Palace J7
  13. Rocafernandez A8
  14. Diaz AR7
  15. Leite MI7
  16. Sharma SM9
  17. Ashtari F10
  18. Kafieh R11
  19. Dehghani A12
  20. Pourazizi M12
  21. Pandit L13
  22. Dcunha A13
  23. Aktas O14
  24. Ringelstein M14, 15
  25. Albrecht P14
  26. May E16
  27. Tongco C16
  28. Leocani L17
  29. Pisa M17
  30. Radaelli M17
  31. Martinezlapiscina EH19
  32. Stiebelkalish H20, 21
  33. Hellmann M20
  34. Lotan I20
  35. Siritho S22
  36. De Seze J23
  37. Senger T23
  38. Havla J24
  39. Marignier R25
  40. Tilikete C26
  41. Cobo Calvo A25
  42. Bichuetti DB27
  43. Tavares IM28
  44. Asgari N29, 30
  45. Soelberg K29, 30
  46. Altintas A31
  47. Yildirim R32
  48. Tanriverdi U33
  49. Jacob A34
  50. Huda S34
  51. Rimler Z35
  52. Reid A35
  53. Maodraayer Y36
  54. De Castillo IS37
  55. Yeaman MR38, 39
  56. Smith TJ40, 41
  57. Brandt AU1, 2, 42
  58. Paul F1, 2, 43
Show Affiliations
Authors Affiliations
  1. 1. Experimental and Clinical Research Center, Max Delbruck Center for Molecular Medicine and Charite, Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health, Berlin, Germany
  2. 2. NeuroCure Clinical Research Center, Charite-Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health, Berlin, Germany
  3. 3. Department of Pediatrics, University of Utah, Salt Lake CIty, UT, United States
  4. 4. Ciem Ms Research Center, University of Minas Gerais, Medical School, Belo Horizonte, Brazil
  5. 5. Department of Neurology, National Cancer Center, Goyang, South Korea
  6. 6. Department of Ophthalmology, National Cancer Center, Goyang, South Korea
  7. 7. Department of Neurology, Oxford University Hospitals, National Health Service Trust, Oxford, United Kingdom
  8. 8. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
  9. 9. Department of Ophthalmology, Oxford University Hospitals, National Health Service Trust, Oxford, United Kingdom
  10. 10. Kashani Ms Center, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  13. 13. Department of Neurology, Ks Hegde Medical Academy, Nitte University, Mangalore, India
  14. 14. Department of Neurology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
  15. 15. Department of Neurology, Center for Neurology and Neuropsychiatry, VR-Klinikum, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
  16. 16. Swedish Neuroscience Institute Neuro-Ophthalmology, Seattle, WA, United States
  17. 17. Neurological Department, Institute of Experimental Neurology (INSPE) Scientific Institute, Hospital San Raffaele
  18. 18. University Vita-Salute San Raffaele, Milan, Italy
  19. 19. Hospital Clinic of Barcelona-Institut d'Investigacions, Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain
  20. 20. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
  21. 21. Neuro-Ophthalmology Division, Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel
  22. 22. Division of Neurology, Department of Medicine, Siriraj Hospital and Bumrungrad International Hospital, Bangkok, Thailand
  23. 23. Neurology Service, University Hospital of Strasbourg, Strasbourg, France
  24. 24. Institute of Clinical Neuroimmunology, University Hospital, Ludwig Maximilians University, Munich, Germany
  25. 25. Neurology, Multiple Sclerosis, Myelin Disorders and Neuroinflammation, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon, France
  26. 26. Department of Neuro-Ophthalmology, Hospices Civils de Lyon, Lyon, France
  27. 27. Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  28. 28. Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  29. 29. Departments of Neurology, Slagelse Hospital, Slagelse, Denmark
  30. 30. Institutes of Regional Health Research and Molecular Medicine, University of Southern Denmark, Odense, Denmark
  31. 31. Neurology Department, School of Medicine, Koc University and Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkiye
  32. 32. Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkiye
  33. 33. Neurology Department Istanbul, Istanbul University, Cerrahpasa School of Medicine, Istanbul, Turkiye
  34. 34. Department of Neurology, Walton Centre Nhs Foundation Trust, Liverpool, United Kingdom
  35. 35. Department of Neurology, Nyu Multiple Sclerosis Comprehensive Care Center, Nyu School of Medicine, New York, NY, United States
  36. 36. Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, United States
  37. 37. Department of Neurology, Hospital Clinico de Maracaibo, Maracaibo, Venezuela
  38. 38. Department of Medicine, Los Angeles Biomedical Research Institute, Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, United States
  39. 39. Department of Medicine, David Geffen School of Medicine at Ucla, Los Angeles, CA, United States
  40. 40. Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, Ann Arbor, MI, United States
  41. 41. Division of Metabolism Endocrine and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, United States
  42. 42. Department of Neurology, University of California, Irvine, CA, United States
  43. 43. Department of Neurology, Charite-Universitatsmedizin Berlin, Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health, Berlin, Germany

Source: BMJ Open Published:2020


Abstract

Purpose Optical coherence tomography (OCT) captures retinal damage in neuromyelitis optica spectrum disorders (NMOSD). Previous studies investigating OCT in NMOSD have been limited by the rareness and heterogeneity of the disease. The goal of this study was to establish an image repository platform, which will facilitate neuroimaging studies in NMOSD. Here we summarise the profile of the Collaborative OCT in NMOSD repository as the initial effort in establishing this platform. This repository should prove invaluable for studies using OCT to investigate NMOSD. Participants The current cohort includes data from 539 patients with NMOSD and 114 healthy controls. These were collected at 22 participating centres from North and South America, Asia and Europe. The dataset consists of demographic details, diagnosis, antibody status, clinical disability, visual function, history of optic neuritis and other NMOSD defining attacks, and OCT source data from three different OCT devices. Findings to date The cohort informs similar demographic and clinical characteristics as those of previously published NMOSD cohorts. The image repository platform and centre network continue to be available for future prospective neuroimaging studies in NMOSD. For the conduct of the study, we have refined OCT image quality criteria and developed a cross-device intraretinal segmentation pipeline. Future plans We are pursuing several scientific projects based on the repository, such as analysing retinal layer thickness measurements, in this cohort in an attempt to identify differences between distinct disease phenotypes, demographics and ethnicities. The dataset will be available for further projects to interested, qualified parties, such as those using specialised image analysis or artificial intelligence applications. © 2020 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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