Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Helicobacter Pylori Seropositivity in Iranian Patients With Vitiligo: A Case-Control Study Publisher



Aghaei M1 ; Aghaei S2 ; Iraji F3 ; Nilforoushzadeh MA4 ; Hosseini SM5 ; Shahmoradi Z6 ; Hejazi SH7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biostatistics & Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Skin Diseases and Leishmaniasis Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Skin Diseases and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Dermatology Published:2024


Abstract

Background: Vitiligo is an autoimmune disease of the skin that affects both sexes and people of any age. The genetic and environmental factors are involved in the vitiligo etiology. Helicobacter pylori (H. pylori) has an important role in vitiligo progression. Therefore, the present study evaluated H. pylori seropositivity in vitiligo patients compared to healthy individuals. Method: H. pylori infection was investigated in 210 vitiligo patients and 127 sex-and age-matched healthy controls using Enzyme-Linked Immunosorbent Assay (ELISA) test. The data was analyzed using SPSS software version 20.0, and the groups were compared using T-test and ANOVA tests. P < 0.05 was considered statistically significant. Resul t s: Vi t i l i go pat i ent s had hi gher medi an l evel s of I gG (29.68 ± 28.28 RU/mL) than (19.08 ± 20.12 RU/mL) in healthy controls (P < 0.000). Moreover, there was no significant difference between groups based on the level of IgM (P < 0.207). In the vitiligo group, IgG or IgM means were different compared to age (P < 0.33)/ (P < 0.017) and early symptoms (P < 0.00) (P < 0.02), respectively. Unlike IgG, there was a significant difference between the mean level of IgM, the onset age of vitiligo (P < 0.022), and the duration of the disease (P < 0.05). Moreover, males and females with vitiligo had a higher seropositivity to H. pylori antibodies than the control group. Conclusion: Vitiligo was found to be significantly associated with H. pylori in Iranian patients. Therefore, it seemed probable that H. pylori had an important role in the initiation or progression of disease activity in vitiligo. © Iranian Journal of Dermatology.
Related Docs
View other Related Docs
1. Comparison of Salivary Anti Helicobacter Pylori Igg With Serum Igg and Bacteriological Tests in Detecting Helicobacter Pylori Infections, Journal of Research in Medical Sciences (2005)
2. Vitiligo and Autoantibodies of Celiac Disease, International Journal of Preventive Medicine (2013)
3. Association Between the Treatment of Rosacea and Eradication of Helicobacter Pylori Infection, Advanced Biomedical Research (2023)
4. Seroprevalence of Helicobacter Pylori Infection in Iranian Adolescents: The Caspian- Iii Study, International Journal of Pediatrics (2017)
5. Helicobacter Pylori's Evasion of the Immune System Could Establish an Inflammatory Environment That Potentially Induces the Development of Coronary Artery Disease, Jundishapur Journal of Microbiology (2013)
6. Helicobacter Pylori in Iran: A Systematic Review on the Association of Genotypes and Gastroduodenal Diseases, Journal of Research in Medical Sciences (2012)
7. Is Helicobacter Pylori Infection a Risk Factor for Coronary Heart Disease?, ARYA Atherosclerosis (2012)
8. Relation of Bab A2 Genotype of Helicobacter Pylori Infection With Chronic Active Gastritis, Duodenal Ulcer and Non-Cardia Active Gastritis in Alzahra Hospital Isfahan, Iran, Jundishapur Journal of Microbiology (2010)
Experts (# of related papers)
View all Related Experts
Mohammad Hossein Sanei (4)
Rasoul Salehi (3)
Other Related Docs
9. Frequency of Virulence Factors in Helicobacter Pylori-Infected Patients With Gastritis, Microbial Pathogenesis (2015)
10. Diagnostic Values of Helicobacter Pylori Diagnostic Tests: Stool Antigen Test, Urea Breath Test, Rapid Urease Test, Serology and Histology, Journal of Research in Medical Sciences (2011)
11. Comparative Immune Response in Children and Adults With H. Pylori Infection, Journal of Immunology Research (2015)
12. Comparison of Four Invasive Methods for Diagnosis of Helicobacter Pylori Infection: Fluorescence in Situ Hybridization, Histology, Culture, Rapid Urease Test, Molecular Genetics, Microbiology and Virology (2020)
13. Thyroid Function and Antithyroid Antibodies in Vitiligo: A Case Control Study, Journal of Isfahan Medical School (2012)
14. Association Between Helicobacter Pylori Infection and Seronegative Neuromyelitis Optica Spectrum Disorder, Caspian Journal of Neurological Sciences (2023)
15. Stool Antigen Tests for the Detection of Helicobacter Pylori in Children, Iranian Journal of Pediatrics (2013)
16. Prevalence of Resistance of Helicobacter Pylori Strains to Selected Antibiotics in Isfahan, Iran, Jundishapur Journal of Microbiology (2013)
17. Is There Any Difference in the Levels of Antibodies Against Helicobacter Pylori Infection Between the Patients With Migraine Headache With or Without Aura?, Journal of Isfahan Medical School (2015)
18. Comparison of the Sensitivity and Specificity of Available Methods in Helicobacter Pylori Infection Detection in Children, Journal of Isfahan Medical School (2013)
19. Virulence Factors of Helicobacter Pylori Vaca Increase Markedly Gastric Mucosal Tgf-Β1 Mrna Expression in Gastritis Patients, Microbial Pathogenesis (2014)
20. Helicobacter Pylori Serum Antibody Titers in Patients With Cerebral Non-Cardioembolic Ischemic Stroke, Journal of Research in Medical Sciences (2011)
21. Immunoblot Assay in Determination of Serum Antibody Profile of Helicobacter Pylori Infection, Iranian Journal of Medical Sciences (2003)
22. The Interaction of Helicobacter Pylori Infection and Type 2 Diabetes Mellitus, Advanced Biomedical Research (2019)
23. Comparative Study on Cost and Effects of Non Invasive Helicobacter Pylori Diagnostic Tests, Journal of Isfahan Medical School (2011)
24. Relationship Between Helicobacter Pylori Immunoglobulin G Antibody and Thrombotic Ischemic Stroke, Acta Medica Iranica (2008)
25. Mucosal Interleukin-21 Mrna Expression Level Is High in Patients With Helicobacter Pylori and Is Associated With the Severity of Gastritis, Central European Journal of Immunology (2015)
26. Association Between Spectrophotometric Assayed of Glucose 6 Phosphate Dehydrogenase (G6pd) Enzyme and Vitiligo, Journal of Knowledge and Health in Basic Medical Sciences (2018)
27. Study of Vac a Genotypes of H.Pylori Isolated From Patients With the Upper Gastrointestinal Diseases by Pcr, Journal of Isfahan Medical School (2009)
28. Associations of a Tlr4 Single-Nucleotide Polymorphism With H.Pylori Associated Gastric Diseases in Iranian Patients, Clinics and Research in Hepatology and Gastroenterology (2014)
29. Helicobacter Pylori As a Zoonotic Infection: The Detection of H. Pylori Antigens in the Milk and Faeces of Cows, Journal of Research in Medical Sciences (2011)
30. Global Clinicoepidemiological Pattern of Childhood Vitiligo: A Systematic Review and Meta-Analysis, BMJ Paediatrics Open (2023)
31. Correlation Between Mucosal Il-6 Mrna Expression Level and Virulence Factors of Helicobacter Pylori in Iranian Adult Patients With Chronic Gastritis, Jundishapur Journal of Microbiology (2015)
32. Seroprevalence of Anti-Helicobacter Pylori Antibodies in Hepatitis B and C Patients With Cirrhosis: A Case-Control Study, Journal of Research in Medical Sciences (2007)
33. Correlation of Caga Positive Helicobacter Pylori Infection With Clinical Outcomes in Alzahra Hospital, Isfahan, Iran, Journal of Research in Medical Sciences (2008)