Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report

Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report Publisher

Ahmadi Tafti SM¹ ; Sharifi A² ; Keshvari A¹ ; Nili F³ ; Safaei M⁴

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1. Colorectal Surgery Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
2. Sina Trauma and Surgery Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Surgery Case Reports Published:2020

Abstract

Introduction: Primary rectal choriocarcinoma is an extremely rare malignancy. The association of these neoplasms in patients with inflammatory bowel disease (IBD) has not been reported. Presentation of case: A 34-year-old female with history of Ulcerative Colitis (UC) gave birth to a male fetus. She had postpartum bleeding and high level of beta-human chorionic gonadotropin (βhCG) was detected. Although initial investigations failed to confirm molar pregnancy, abnormal uterine bleeding and high βhCG level necessitate chemotherapy administration. She did not respond to chemotherapy sessions accordingly. Meanwhile, the patient experienced rectorrhagia and colonoscopy revealed a firm submucosal polypoid lesion 8–10 cm from the anal verge. The multidisciplinary team candidate the patient for total proctocolectomy and ileal pouch anal anastomosis. Although postoperative course was uneventful and βhCG level dropped but it showed a rising pattern in follow ups. Chemotherapy was planned but there was not suitable response. Unfortunately, the patient passed away 20 months after the initial diagnosis. Discussion: Pathology report indicated the coexistence of moderately differentiated tubular adenocarcinoma and choriocarcinoma. We assume previous history of UC might have put her at higher susceptibility to develop carcinoma and this poorly differentiated carcinoma has led to choriocarcinoma. Considering the fact that in most cases of colorectal choriocarcinoma, choriocarcinomatous differentiation was found alongside colonic adenocarcinoma made dedifferentiation theory to be the most acceptable explanation. Conclusion: The adenocarcinoma of the colon and rectum in the setting of IBD may become so dedifferentiated that gain some characteristics of germ cell tumors. © 2020

Style	Citing Format
MLA	Ahmadi Tafti SM, et al.. "Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report." International Journal of Surgery Case Reports, vol. 77, no. , 2020, pp. 256-259.
APA	Ahmadi Tafti SM, Sharifi A, Keshvari A, Nili F, Safaei M (2020). Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report. International Journal of Surgery Case Reports, 77(), 256-259.
Chicago	Ahmadi Tafti SM, Sharifi A, Keshvari A, Nili F, Safaei M. "Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report." International Journal of Surgery Case Reports 77, no. (2020): 256-259.
Harvard	Ahmadi Tafti SM et al. (2020) 'Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report', International Journal of Surgery Case Reports, 77(), pp. 256-259.
Vancouver	Ahmadi Tafti SM, Sharifi A, Keshvari A, Nili F, Safaei M. Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report. International Journal of Surgery Case Reports. 2020;77():256-259.
BibTex	@article{ author = {Ahmadi Tafti SM and Sharifi A and Keshvari A and Nili F and Safaei M}, title = {Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report}, journal = {International Journal of Surgery Case Reports}, volume = {77}, number = {}, pages = {256-259}, year = {2020} }
RIS	TY - JOUR AU - Ahmadi Tafti SM AU - Sharifi A AU - Keshvari A AU - Nili F AU - Safaei M TI - Primary Rectal Choriocarcinoma Associated With Rectal Adenocarcinoma in a Woman With a History of Ulcerative Colitis: Case Report JO - International Journal of Surgery Case Reports VL - 77 IS - SP - 256 EP - 259 PY - 2020 ER -

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