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From Kitchen to Clinic: Pharmacotherapeutic Potential of Common Spices in Indian Cooking in Age-Related Neurological Disorders Publisher



Norouzkhani N1 ; Karimi AG2 ; Badami N3 ; Jalalifar E4 ; Mahmoudvand B5 ; Ansari A6 ; Pakrou Sariyarighan N7 ; Alijanzadeh D8 ; Aghakhani S9 ; Shayestehmehr R10 ; Arzaghi M11 ; Sheikh Z12 ; Salami Y13 ; Marabi MH14 Show All Authors
Authors
  1. Norouzkhani N1
  2. Karimi AG2
  3. Badami N3
  4. Jalalifar E4
  5. Mahmoudvand B5
  6. Ansari A6
  7. Pakrou Sariyarighan N7
  8. Alijanzadeh D8
  9. Aghakhani S9
  10. Shayestehmehr R10
  11. Arzaghi M11
  12. Sheikh Z12
  13. Salami Y13
  14. Marabi MH14
  15. Abdi A14
  16. Deravi N8
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Cardiovascular Imaging Core Facility, Tehran University of Medical Sciences, Tehran, Preclinical, Iran
  3. 3. Pharmaceutical Sciences Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  4. 4. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  7. 7. School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  8. 8. Student Research committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Student Research Committee, Esfahan University of Medical Sciences, Esfahan, Iran
  10. 10. Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran
  11. 11. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Babol University of Medical Sciences, Babol, Iran
  13. 13. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  14. 14. Student Research Committee, School of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Frontiers in Pharmacology Published:2022


Abstract

Aging is described as an advanced time-related collection of changes that may negatively affect with the risk of several diseases or death. Aging is a main factor of several age-related neurological disorders, including neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, and dementia), stroke, neuroinflammation, neurotoxicity, brain tumors, oxidative stress, and reactive oxygen species (ROS). Currently available medications for age-related neurological disorders may lead to several side effects, such as headache, diarrhea, nausea, gastrointestinal (GI) diseases, dyskinesia, and hallucinosis. These days, studies on plant efficacy in traditional medicine are being conducted because herbal medicine is affordable, safe, and culturally acceptable and easily accessible. The Indian traditional medicine system called Ayurveda uses several herbs and medicinal plants to treat various disorders including neurological disorders. This review aims to summarize the data on the neuroprotective potential of the following common Indian spices widely used in Ayurveda: cumin (Cuminum cyminum (L.), Apiaceae), black cumin (Nigella sativa (L.), Ranunculaceae), black pepper (Piper nigrum (L.), Piperaceae), curry leaf tree (Murraya koenigii (L.), Spreng Rutaceae), fenugreek (Trigonella foenum-graecum (L.), Fabaceae), fennel (Foeniculum vulgare Mill, Apiaceae), cardamom (Elettaria cardamomum (L.) Maton, Zingiberaceae), cloves (Syzygium aromaticum (L.) Merr. & L.M.Perry, Myrtaceae), and coriander (Coriandrum sativum (L.), Apiaceae) in age-related neurological disorders. Copyright © 2022 Norouzkhani, Karimi, Badami, Jalalifar, Mahmoudvand, Ansari, Pakrou Sariyarighan, Alijanzadeh, Aghakhani, Shayestehmehr, Arzaghi, Sheikh, Salami, Marabi, Abdi and Deravi.
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