Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Influence of Psychological Stress on the Initiation and Progression of Diabetes and Cancer Publisher



Afrisham R1 ; Paknejad M1 ; Soliemanifar O2 ; Sadeghnejadi S1 ; Meshkani R1 ; Ashtarylarky D3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. General Department of Education in Khuzestan Province, Department of Education in the City of Khorramshahr, Khorramshahr, Iran
  3. 3. Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  4. 4. Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: International Journal of Endocrinology and Metabolism Published:2019


Abstract

Context: Psychological stress can be considered a risk factor for the initiation and progression of many pathological conditions, including type 1 and 2 diabetes mellitus and cancer. Objectives: The aim of this review article was to evaluate the molecular and cellular mechanisms linking psychological stress to the onset and progression of diabetes and cancer. Evidence Acquisition: The current review was conducted to survey and analyze studies related to the effects of psychological stress on diabetes and cancer. Results: Psychological stress may make individuals prone to the development of diabetes through the impairment of the hypotha-lamic–pituitary–adrenal (HPA) axis function, sympathetic nerves system (SNS), lipid profile, cytokines balance, renin-angiotensin system (RAS), and insulin signaling pathway. Additionally, psychological stress can contribute to the development of cancer through the perturbation in the HPA axis, SNS function, and cytokines balance. Psychological stress is also capable of decreasing the levels of oxytocin and dopamine, leading to an increased risk of cancer in susceptible individuals. Conclusions: It seems that psychological stress plays a significant role in the onset and progression of diabetes and cancer. The identification of the pathways triggered by psychological stress would open up a new avenue for the understanding of molecular mechanisms by which diabetes and cancer could be managed or even prevented. Copyright © 2019, International Journal of Endocrinology and Metabolism.
Related Docs
1. Relationship Between Personality and Biological Reactivity to Stress: A Review, Psychiatry Investigation (2018)
2. The Expression of Dopamine Receptors Gene and Their Potential Role in Targeting Breast Cancer Cells With Selective Agonist and Antagonist Drugs. Could It Be the Novel Insight to Therapy?, Current Drug Discovery Technologies (2019)
3. The Potential Therapeutic Impact of Metformin in Glioblastoma Multiforme, Current Medicinal Chemistry (2023)
4. Polycystic Ovary Syndrome and Sympathoexcitation: Management of Stress and Lifestyle, Journal of Biology and Today's World (2017)
5. Salivary Testosterone Levels Under Psychological Stress and Its Relationship With Rumination and Five Personality Traits in Medical Students, Psychiatry Investigation (2016)
6. Association of Microrna Gene Polymorphisms With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2020)
7. The Role of Myeloid-Derived Suppressor Cells in Lung Cancer and Targeted Immunotherapies, Expert Review of Anticancer Therapy (2022)
8. Dopamine Receptors Gene Overexpression in the Microenvironment of Invasive Gastric Cancer and Its Potential Implications, Molecular Biology Reports (2023)
Experts (# of related papers)
View all Related Experts
Reza Afrisham (2)
Farideh Razi (1)