Effects of Eicosapentaenoic Acid Supplementation on Heat Shock Protein 27, Glycemic Status and Anthropometric Indices in Type 2 Diabetes Patients Publisher



Ghaedi E^{1, 2} ; Sharifdini JG¹ ; Javanbakht MH¹ ; Mohammadi H³ ; Golzari MH¹ ; Zarei M¹ ; Hadi A⁴ ; Djalali M^{1, 5} Show Affiliations
Source: Journal of Diabetes and Metabolic Disorders Published:2023

Abstract

Purpose: Heat shock proteins (HSP-27) are reported to be involved in the pathophysiology of diabetes complications. The purpose of the current study is to assess the effects of eicosapentaenoic acid (EPA) supplementation on serum HSP-27, glycemic status and anthropometric indices in type 2 diabetes mellitus (T2DM) patients. Methods: Thirty-six patients with T2DM were randomly allocated to obtain 2 g per day EPA (n = 18) or placebo (n = 18) for 8 weeks in a randomized, double-blind, placebo-controlled clinical trial. Fasting serum levels of HSP 27, fasting blood sugar, hemoglobin A1C, as well as anthropometric indices were measured. Results: EPA supplementation reduces the serum level of HSP 27 in the EPA group compared with the placebo (P < 0.03). Although waist circumference (WC) decreased significantly in the EPA group at the end of the trial (P < 0.02), there was no significant difference in weight, WC, body mass index (BMI), and glycemic markers in both groups after intervention (P > 0.05). Conclusions: We found that EPA supplementation reduces HSP 27 serum level in T2DM patients. However, future large-scale trials are needed. © 2022, The Author(s), under exclusive licence to Tehran University of Medical Sciences.