Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials

Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials Publisher Pubmed

Tavakoli K¹ ; Mohammadi NSH¹ ; Bahiraie P² ; Saeidi S¹ ; Shaker F¹ ; Moghadam AS¹ ; Namin SM¹ ; Rahban H^{3, 4} ; Pawar S⁵ ; Tajdini M^{1, 6} ; Soleimani H^{1, 6} ; Jenab Y^{1, 6} ; Ahmad Y⁷ ; Iskander FH⁸ Show All Authors

Tavakoli K¹
Mohammadi NSH¹
Bahiraie P²
Saeidi S¹
Shaker F¹
Moghadam AS¹
Namin SM¹
Rahban H^{3, 4}
Pawar S⁵
Tajdini M^{1, 6}
Soleimani H^{1, 6}
Jenab Y^{1, 6}
Ahmad Y⁷
Iskander FH⁸
Alkhouli M⁹
Makkar R⁵
Gupta A⁵
Hosseini K^{1, 6}

Show Affiliations

1. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Cardiovascular Research Foundation of Southern California, Beverly Hills, CA, United States
4. Department of Cardiovascular Disease, Creighton University School of Medicine, St. Joseph Hospital and Medical Center, Phoenix, AZ, United States
5. Cedars Sinai Medical Center, California, United States
6. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
7. Yale School of Medicine, Yale University, New Haven, CT, United States
8. Department of Cardiology, Medstar Union Memorial Hospital, Baltimore, MD, United States
9. Department of Cardiology, Mayo Clinic School of Medicine, Rochester, MN, United States

Source: Clinical Cardiology Published:2025

Abstract

Background: Comparisons of outcomes after transcatheter aortic valve replacement with balloon-expandable (BEV) versus self-expanding (SEV) valves are limited. Hypothesis: This study aimed to compare clinical and hemodynamic outcomes of BEV and SEV at short-term (30 days), midterm (1 year), and long-term (> 1 year) endpoints. Methods: PubMed, Embase, Scopus, and Cochrane Library databases were searched until July 2024 for randomized controlled trials. Random-effect model (DerSimonian–Laird method) was used to pool the risk ratios (RR), mean differences, and 95% confidence intervals (CI). Results: A total of 10 studies comprising 4325 patients (2295 BEV, 2030 SEV) were included. In short-term, cardiovascular (RR: 0.56, 95% CI: 0.36–0.87) and all-cause mortality (RR: 0.54, 95% CI: 0.35–0.81) were lower in the BEV group. Risk of moderate to severe paravalvular leak (PVL) was lower among BEV patients in short-term (RR: 0.28, 95% CI: 0.17–0.49) and long-term (RR: 0.28, 95% CI: 0.1–0.79). A limited number of studies showed a greater risk of clinical valve thrombosis on BEV in midterm and long-term. The need for permanent pacemaker implantation was lower in BEV at both short-term (RR: 0.56, 95% CI: 0.37–0.87), and midterm (RR: 0.78, 95% CI: 0.64–0.94). The SEV group had a larger effective orifice area with lower mean transvalvular pressure gradient at all endpoints. Conclusions: BEV is associated with reduced risk of clinical outcomes in short-term; however, most differences diminish in longer evaluations, except for moderate to severe PVL, which remains elevated for SEV. SEVs had better hemodynamic results and lower risk of clinical valve thrombosis. © 2025 The Author(s). Clinical Cardiology published by Wiley Periodicals, LLC.

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Style	Citing Format
MLA	Tavakoli K, et al.. "Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials." Clinical Cardiology, vol. 48, no. 4, 2025, pp. -.
APA	Tavakoli K, Mohammadi NSH, Bahiraie P, Saeidi S, Shaker F, Moghadam AS, Namin SM, Rahban H, Pawar S, Tajdini M, Soleimani H, Jenab Y, Ahmad Y, Iskander FH, Alkhouli M, Makkar R, Gupta A, Hosseini K (2025). Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials. Clinical Cardiology, 48(4), -.
Chicago	Tavakoli K, Mohammadi NSH, Bahiraie P, Saeidi S, Shaker F, Moghadam AS, Namin SM, et al.. "Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials." Clinical Cardiology 48, no. 4 (2025): -.
Harvard	Tavakoli K et al. (2025) 'Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials', Clinical Cardiology, 48(4), pp. -.
Vancouver	Tavakoli K, Mohammadi NSH, Bahiraie P, Saeidi S, Shaker F, Moghadam AS, et al.. Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials. Clinical Cardiology. 2025;48(4):-.
BibTex	@article{ author = {Tavakoli K and Mohammadi NSH and Bahiraie P and Saeidi S and Shaker F and Moghadam AS and Namin SM and Rahban H and Pawar S and Tajdini M and Soleimani H and Jenab Y and Ahmad Y and Iskander FH and Alkhouli M and Makkar R and Gupta A and Hosseini K}, title = {Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials}, journal = {Clinical Cardiology}, volume = {48}, number = {4}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Tavakoli K AU - Mohammadi NSH AU - Bahiraie P AU - Saeidi S AU - Shaker F AU - Moghadam AS AU - Namin SM AU - Rahban H AU - Pawar S AU - Tajdini M AU - Soleimani H AU - Jenab Y AU - Ahmad Y AU - Iskander FH AU - Alkhouli M AU - Makkar R AU - Gupta A AU - Hosseini K TI - Short-Term, Mid-Term, and Long-Term Outcomes of Transcatheter Aortic Valve Replacement With Balloon-Expandable Versus Self-Expanding Valves: A Meta-Analysis of Randomized Controlled Trials JO - Clinical Cardiology VL - 48 IS - 4 SP - EP - PY - 2025 ER -

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