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Microextraction Techniques in Antibiotic Monitoring in Body Fluids: Recent Trends and Future Publisher



Jafari S1 ; Hamidi S2
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Biomaterial, School of Pharmacy and Medical Biomaterials Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Food and Drug Safety Research Center, Tabriz University of Medical Science, Tabriz, Iran

Source: Journal of Liquid Chromatography and Related Technologies Published:2018


Abstract

The analysis of drugs in biomedical discipline targets a broad range of aims such as therapeutic drug monitoring, pharmacokinetic study to investigate the drug bioavailability, bioequivalence tests to evaluate the effect of formulation parameters, toxicology, and forensic science. Because of the low levels of typical antibiotics in plasma, blood, urine, exhalation samples, and other biological fluids as well as complex matrix of biological media, adequate sample preparation methods should be implemented for quantification of antibiotics. In this review, developments in well-established microextraction techniques for the clinical analysis of biological samples will be reviewed and discussed. This article presents an overview of microextraction methods for biological samples, focusing especially on antibiotics. © 2018 Taylor & Francis.
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