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Preparation, Characterization and Cytotoxic Effects of Pegylated Nanoliposomal Containing Carboplatin on Ovarian Cancer Cell Lines Publisher



Ebrahimifar M1 ; Niliahmadabadi A2 ; Akbarzadeh A3 ; Shahemabadi HE4 ; Hasanzadegan M5 ; Moradisardareh H6 ; Madadizadeh H1 ; Rezaeediyan J7
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Authors Affiliations
  1. 1. Department of Toxicology, Faculty of Pharmacy, Islamic Azad University, Shahreza Branch, Shahreza, Iran
  2. 2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hamadan University of Medical Sciences, P.O. Box 8678-3-65178, Hamadan, Iran
  3. 3. Department of Pilot Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Microbiology, Parasitology and Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  5. 5. Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  6. 6. Department of Biochemistry, Tehran University of Medical Science, Tehran, Iran
  7. 7. Department of Genetics, School of Advanced Sciences in Medicine, Islamic Azad University, Tehran, Iran

Source: Indian Journal of Clinical Biochemistry Published:2017


Abstract

Carboplatin is a chemotherapeutic agent used against various malignancies such as ovarian carcinoma. The aim of this study is to improve the therapeutic efficacy of carboplatin using pegylated liposomal nanocarriers. Nanoparticles were synthesized using thin film hydration technique and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, A2780S and A2780CP ovarian cancer cell lines were used to determine the efficacy of nanodrug by MTT assay. The particle size and zeta potential of nanodrug were measured 244.3 ± 19.6 nm and −22.9 ± 1.7 mV, respectively. High encapsulation capacity (78.6 ± 3.7 %) confirmed the efficiency of technique. The cytotoxicity results also showed that nanodrug compared to free drug improve the efficacy of carboplatin against both A2780S (P < 0.01) and A2780CP (P < 0.05) cell lines. In conclusion, the findings of our study suggested pegylated liposomal nanocarriers are proper for carboplatin delivery to ovarian cancer cell lines A2780S and A2780CP. © 2016, Association of Clinical Biochemists of India.
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