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Optimizing Outcomes in Heart Transplantation: The Role of High-Intensity Statin Therapy Publisher Pubmed



Ghavamikia N1 ; Saffarfar H2 ; Seifdavati B3 ; Jamali M4 ; Izadidehkordi S5 ; Pakmehr SA6 ; Aghabali M7 ; Jahani N8 ; Alikhiavi P9 ; Soleimanian A7 ; Hijazi A10 ; Vahedinezhad M11 ; Shahhoseini R12
Authors
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Authors Affiliations
  1. 1. Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cardiovascular Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore, India
  5. 5. Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  8. 8. Student Research Committee, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia
  11. 11. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  12. 12. Faculty of Medicine, Istanbul Medipol University, Istanbul, Turkey

Source: Journal of Biochemical and Molecular Toxicology Published:2024


Abstract

Heart transplantation is a vital procedure for patients with end-stage heart failure, but it faces significant challenges, including graft dysfunction, rejection, and cardiac allograft vasculopathy (CAV), which can compromise long-term graft success. Research suggests that statin therapy may offer significant benefits to heart transplant recipients, such as improved long-term survival and reduced rates of graft rejection and mortality. The aim of this review is to thoroughly examine the recent literature on this topic since 2005. Early use of high-dose statins appears to be particularly effective in preventing vasculopathy and improving outcomes, although a titrated approach may help to reduce side effects. High-dose statins may provide superior cardiovascular benefits, including lower rates of CVD, slower progression of CVD and improved long-term graft survival. Despite potential concerns about adverse effects, evidence suggests that high-intensity statins improve cholesterol levels without increasing serious adverse events after transplantation. The goal of statin therapy in heart transplant recipients is to balance the well-established benefits seen in the general population with the specific needs of this group, with the ultimate goal of improving both longevity and quality of life. © 2024 Wiley Periodicals LLC.
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