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Platinum and Gold Nanoparticles As Radiosensitizers in Megavoltage Radiotherapy: Quantitative Assessment Via Mri Polymer Gel Dosimetry Publisher



Shoobkolaei S ; Riyahi Alam N ; Monfared AS ; Khobi M ; Farahani S
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Source: Radiation Physics and Chemistry Published:2026


Abstract

Enhancing the therapeutic ratio in radiotherapy using metal nanoparticles is a promising approach to improve tumor control while sparing healthy tissue. Platinum nanoparticles (PtNPs), due to their high atomic number and electron density, are considered strong candidates for dose enhancement in radiotherapy. In this study, we conducted a quantitative dosimetric comparison of the radiosensitizing effects of 0.1 mM platinum nanoparticles and gold nanoparticles (AuNPs) using MAGICA polymer gel dosimetry under 6 MV Xray irradiation. Gel samples containing AuNPs, PtNPs, and a control were irradiated with a clinical linear accelerator, and transverse relaxation rates (R2 = 1/T2) were measured via T2-weighted MRI. Dose enhancement factors, calculated from changes in R2, were 9.88 ± 0.38 % for AuNPs and 12.04 ± 0.45 % for PtNPs, demonstrating significantly greater dose amplification by PtNPs under megavoltage irradiation (p ≤ 0.05). This study highlights the capability of polymer gel dosimetry to provide a direct, quantitative evaluation of nanoparticle-induced dose enhancement in clinically relevant megavoltage settings. Copyright © 2025. Published by Elsevier Ltd.
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