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Hyperglycemic Memory: Observational Evidence to Experimental Inference Publisher Pubmed



Ahmadi M1 ; Ghafourifard S1 ; Najarihanjani P2 ; Morshedzadeh F3 ; Malakoutian T4 ; Abbasi M5, 6 ; Akbari H4 ; Amoli MM7 ; Saffarzadeh N4, 8
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Genetics, Faculty of Basic Sciences, Islamic Azad University, Shahrekord Branch, Iran
  4. 4. Department of Nephrology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Emergency Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Hasheminejad Kidney Centre, Iran University of Medical Sciences, Anesthesiology Section, Tehran, Iran
  7. 7. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Current diabetes reviews Published:2025


Abstract

Several epidemiological studies have appreciated the impact of duration and level of hyperglycemia on the initiation and development of chronic complications of diabetes. However, glycemic profiles could not fully explain the presence/absence and severity of diabetic complications. Genetic issues and concepts of hyperglycemic memory have been introduced as additional influential factors involved in the pathobiology of late complications of diabetes. In the extended phase of significant diabetes randomized, controlled clinical trials, including DCCT/EDIC and UKPDS, studies have concluded that the quality of glycemic or metabolic control at the early time around the diabetes onset could maintain its protective or detrimental impact throughout the following diabetes course. There is no reliable indication of the mechanism by which the transient exposure to a given glucose concentration level could evoke a consistent cellular response at target tissues at the molecular levels. Some biological phenomena, such as the production and the concentration of advanced glycation end products (AGEs), reactive oxygen species (ROS) and protein kinase C (PKC) pathway activations, epigenetic changes, and finally, the miRNAs-mediated pathways, may be accountable for the development of hyperglycemic memory. This work summarizes evidence from previous experiments that may substantiate the hyperglycemic memory soundness by its justification in molecular terms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.