Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans

Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans Publisher Pubmed

Hadjighassem M^{1, 5} ; Kamalidehghan B² ; Shekarriz N³ ; Baseerat A³ ; Molavi N³ ; Mehrpour M⁴ ; Joghataei MT^{1, 6} ; Tondar M⁷ ; Ahmadipour F² ; Meng GY⁸

Show Affiliations

1. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
2. Department of Pharmacy, Faculty of Medicine, University of Malaya (UM), Kuala Lumpur, Malaysia
3. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
4. Department of Neurology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
5. Brain and Spinal Cord Research Center, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
7. Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, United States
8. Department of Animal Science, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia

Source: Nutrition Journal Published:2015

Abstract

Background aims: Dietary omega-6 and omega-3 fatty acids have remarkable impacts on the levels of DHA in the brain and retina. Low levels of DHA in plasma and blood hamper visual and neural development in children and cause dementia and cognitive decline in adults. The level of brain-derived neurotrophic factors (BDNF) changes with dietary omega-3 fatty acid intake. BDNF is known for its effects on promoting neurogenesis and neuronal survival. Methods: In this study, we examined the effect of the oral consumption of α-Linolenic acid (ALA) on blood levels of BDNF and Malondialdehyde (MDA) in healthy adult humans. 30 healthy volunteers, 15 men and 15 women, were selected randomly. Each individual served as his or her own control. Before consuming the Flaxseed oil capsules, 5cc blood from each individual was sampled in order to measure the plasma levels of BDNF and MDA as baseline controls. During the experiment, each individual was given 3 oral capsules of flaxseed oil, containing 500mg of alpha linolenic acid, daily for one week. Then, plasma levels of BDNF and MDA were tested. Results: The plasma levels of BDNF and MDA significantly (P < 0.05) increased in individuals who received the oral capsules of ALA. Plasma levels of BDNF increased more in the women in comparison with the men. Conclusion: ALA treatment could be a feasible approach to reduce size of infarcts in stroke patients. Thus, ALA could be used in adjunction with routine stroke therapies to minimize brain lesions caused by stroke. © 2015 Hadjighassem et al.; licensee BioMed Central.

2. The Effect of Insomnia on Development of Alzheimer's Disease, Journal of Neuroinflammation (2020)

3. The Regulatory Role of Bdnf in Neuroimmune Axis Function and Neuroinflammation Induced by Chronic Stress: A New Therapeutic Strategies for Neurodegenerative Disorders, Cytokine (2024)

4. Intranasal Insulin Intake and Exercise Improve Memory Function in Amyloid-Β Induced Alzheimer's-Like Disease in Rats: Involvement of Hippocampal Bdnf-Trkb Receptor, Behavioural Brain Research (2024)

5. The Role of Omega-3 on Modulation of Cognitive Deficiency Induced by Rem Sleep Deprivation in Rats, Behavioural Brain Research (2018)

6. Omega-3 Fatty Acids' Effect on Leptin and Adiponectin Concentrations in Patients With Spinal Cord Injury: A Double-Blinded Randomized Clinical Trial, Journal of Spinal Cord Medicine (2015)

7. Dysfunction in Brain-Derived Neurotrophic Factor Signaling Pathway and Susceptibility to Schizophrenia, Parkinson’S and Alzheimer’S Diseases, Current Gene Therapy (2018)

8. Sex Steroids-Induced Neurogenesis in Adult Brain: A Better Look at Mechanisms and Mediators, Hormone Molecular Biology and Clinical Investigation (2021)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (2)

Seyed Hasan Emami-Razavi (1)

Style	Citing Format
MLA	Hadjighassem M, et al.. "Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans." Nutrition Journal, vol. 14, no. 1, 2015, pp. -.
APA	Hadjighassem M, Kamalidehghan B, Shekarriz N, Baseerat A, Molavi N, Mehrpour M, Joghataei MT, Tondar M, Ahmadipour F, Meng GY (2015). Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans. Nutrition Journal, 14(1), -.
Chicago	Hadjighassem M, Kamalidehghan B, Shekarriz N, Baseerat A, Molavi N, Mehrpour M, Joghataei MT, Tondar M, Ahmadipour F, Meng GY. "Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans." Nutrition Journal 14, no. 1 (2015): -.
Harvard	Hadjighassem M et al. (2015) 'Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans', Nutrition Journal, 14(1), pp. -.
Vancouver	Hadjighassem M, Kamalidehghan B, Shekarriz N, Baseerat A, Molavi N, Mehrpour M, et al.. Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans. Nutrition Journal. 2015;14(1):-.
BibTex	@article{ author = {Hadjighassem M and Kamalidehghan B and Shekarriz N and Baseerat A and Molavi N and Mehrpour M and Joghataei MT and Tondar M and Ahmadipour F and Meng GY}, title = {Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans}, journal = {Nutrition Journal}, volume = {14}, number = {1}, pages = {-}, year = {2015} }
RIS	TY - JOUR AU - Hadjighassem M AU - Kamalidehghan B AU - Shekarriz N AU - Baseerat A AU - Molavi N AU - Mehrpour M AU - Joghataei MT AU - Tondar M AU - Ahmadipour F AU - Meng GY TI - Oral Consumption of Α-Linolenic Acid Increases Serum Bdnf Levels in Healthy Adult Humans JO - Nutrition Journal VL - 14 IS - 1 SP - EP - PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract