Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains

Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains Publisher

Alimehr S¹ ; Shekari Ebrahim Abad H² ; Shahverdi A³ ; Hashemi J¹ ; Zomorodian K⁴ ; Moazeni M⁵ ; Vosoghian S² ; Rezaie S¹

Show Affiliations

1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2. Pediatric Infections Research Center, Mofid Childrenâ€™s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5. Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Source: Archives of Pediatric Infectious Diseases Published:2015

Abstract

Background: Opportunistic fungi cause fungal infections. Whereas some microorganisms are resistant to chemical drugs, scientists are looking for new natural and inorganic antimicrobial agents. The recent research on metal nanoparticles showed that silver nanoparticles (nanosilver) exhibits lower toxicity to mammalian cells and higher toxicity to microorganisms. Objectives: This study aimed to compare the difference between antimicrobial effect of nanosilver and some antibiotic agents on Candida albicans. Materials and Methods: We studied effect of fluconazole, nanosilver, and their combination on 20 fluconazole-resistant C. albicans from two centers and one standard sample (ATCC10261) by minimal inhibitory concentration (MIC) method. Results: Result of fungi static and fungicidal activities of nanosilver plus fluconazole on fluconazole-resistant C. albicans showed better inhibitory effect on the growth of standard C. albicans when MIC of fluconazole (8 μg/mL) combined with MIC of Nanosilver (0.0625 μg/mL). Conclusions: Totally, our results showed nanosilver caused an increase of at least nine-fold in inhibitory effect of fluconazole. © 2015, Pediartric Infections Research Center.

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Sassan Rezaie (1)

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Style	Citing Format
MLA	Alimehr S, et al.. "Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains." Archives of Pediatric Infectious Diseases, vol. 3, no. 2, 2015, pp. -.
APA	Alimehr S, Shekari Ebrahim Abad H, Shahverdi A, Hashemi J, Zomorodian K, Moazeni M, Vosoghian S, Rezaie S (2015). Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains. Archives of Pediatric Infectious Diseases, 3(2), -.
Chicago	Alimehr S, Shekari Ebrahim Abad H, Shahverdi A, Hashemi J, Zomorodian K, Moazeni M, Vosoghian S, Rezaie S. "Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains." Archives of Pediatric Infectious Diseases 3, no. 2 (2015): -.
Harvard	Alimehr S et al. (2015) 'Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains', Archives of Pediatric Infectious Diseases, 3(2), pp. -.
Vancouver	Alimehr S, Shekari Ebrahim Abad H, Shahverdi A, Hashemi J, Zomorodian K, Moazeni M, et al.. Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains. Archives of Pediatric Infectious Diseases. 2015;3(2):-.
BibTex	@article{ author = {Alimehr S and Shekari Ebrahim Abad H and Shahverdi A and Hashemi J and Zomorodian K and Moazeni M and Vosoghian S and Rezaie S}, title = {Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains}, journal = {Archives of Pediatric Infectious Diseases}, volume = {3}, number = {2}, pages = {-}, year = {2015} }
RIS	TY - JOUR AU - Alimehr S AU - Shekari Ebrahim Abad H AU - Shahverdi A AU - Hashemi J AU - Zomorodian K AU - Moazeni M AU - Vosoghian S AU - Rezaie S TI - Comparison of Difference Between Fluconazole and Silver Nanoparticles in Antimicrobial Effect on Fluconazole-Resistant Candida Albicans Strains JO - Archives of Pediatric Infectious Diseases VL - 3 IS - 2 SP - EP - PY - 2015 ER -

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