The Effects of Whole-Body Vibration on Muscle Parameters, Biomechanical and Metabolic Factors in Diabetic Sarcopenia Patients: Study Protocol of a Randomized Controlled Clinical Trial Publisher



Behbahani MA ; Boozari S ; Bahrpeyma F ; Mohajeritehrani MR ; Heshmat R ; Shafiee G
Source: Journal of Diabetes and Metabolic Disorders Published:2026

Abstract

Background: Sarcopenia, characterized by a reduction in muscle mass and strength can coexist with type Ⅱ diabetes. Effective physical therapy strategies are essential for improving the muscle strength and quality of life in sarcopenic and diabetic patients. Whole Body Vibration (WBV) has emerged as a promising physical therapy intervention with potential benefits for muscle strength, balance, and blood biomarkers. Based on the beneficial effects of WBV on people with sarcopenia and on diabetic patients, it seems that WBV also can be useful in people with diabetic sarcopenia. This study aims to evaluate the effects of WBV on muscle parameters, biomechanical and metabolic factors in older adults with diabetic sarcopenia through a randomized controlled trial. Methods: This study is a randomized controlled trial which will enroll 60 individuals with diabetic sarcopenia. Participants will be randomly assigned to a WBV intervention group and a control group. The WBV group will undergo 36 treatment sessions over 12 weeks, while the control group will be recommended to receive a leaflet about physical activity and diet. Planned outcome: Primary Outcomes include muscle mass, biomechanical parameters of gait and balance, physical function and quality of life. Secondary Outcomes would be muscle strength, blood and inflammatory biomarkers. Data will be collected and analyzed at baseline and post-intervention. A paired sample t -test will be used to compare within-group differences. An ANCOVA will be used to compare between-group differences. A two-sided P < 0.05 will be considered statistically significant. Trial registration: Iranian Registry of Clinical Trials (IRCT), IRCT20201128049511N6 ID in 2024–01-16. © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2026.