Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging

Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging Publisher Pubmed

Tafakhori A¹ ; Parvizi M² ; Farzanefar S³ ; Ahmadzadehfar H⁴ ; Khalaj A⁵ ; Naseri M³ ; Abbasi M³

Show Affiliations

1. Department of Neurology, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, 1419731351, Iran
4. Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Acta Neurologica Belgica Published:2019

Abstract

Magnetic resonance imaging (MRI) and computed tomography (CT) are not always conclusive for the detection of cerebral venous sinus thrombosis (CVST). 99mTc-HMPAO-labeled platelets may be useful in cases with high clinical suspicion. Three patients with headaches with or without intraparenchymal hemorrhage that were highly suspected to have CVST, despite inconclusive anatomical imaging, were selected for inclusion in the study. Platelets were extracted by two rounds of centrifugation from 49 ml of the patient’s whole blood. The platelets were labeled with 99mTc-HMPAO and any unbound 99mTc was removed by centrifugation. The re-suspension of 99mTc-HMPAO-labeled platelets in cell-free plasma was reinjected into the patients. After 2 h, planar and single photon emission computed tomography (SPECT) images of the head were obtained. Extensive clots were detected in all three patients, illustrated in the planar image and even clearer in the SPECT images. We propose that 99mTc-HMPAO-labeled platelet scan is a favorable imaging method for patients suspected to have CVST with inconclusive CT and MRI results. © 2019, Belgian Neurological Society.

Style	Citing Format
MLA	Tafakhori A, et al.. "Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging." Acta Neurologica Belgica, vol. 119, no. 4, 2019, pp. 549-553.
APA	Tafakhori A, Parvizi M, Farzanefar S, Ahmadzadehfar H, Khalaj A, Naseri M, Abbasi M (2019). Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging. Acta Neurologica Belgica, 119(4), 549-553.
Chicago	Tafakhori A, Parvizi M, Farzanefar S, Ahmadzadehfar H, Khalaj A, Naseri M, Abbasi M. "Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging." Acta Neurologica Belgica 119, no. 4 (2019): 549-553.
Harvard	Tafakhori A et al. (2019) 'Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging', Acta Neurologica Belgica, 119(4), pp. 549-553.
Vancouver	Tafakhori A, Parvizi M, Farzanefar S, Ahmadzadehfar H, Khalaj A, Naseri M, et al.. Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging. Acta Neurologica Belgica. 2019;119(4):549-553.
BibTex	@article{ author = {Tafakhori A and Parvizi M and Farzanefar S and Ahmadzadehfar H and Khalaj A and Naseri M and Abbasi M}, title = {Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging}, journal = {Acta Neurologica Belgica}, volume = {119}, number = {4}, pages = {549-553}, year = {2019} }
RIS	TY - JOUR AU - Tafakhori A AU - Parvizi M AU - Farzanefar S AU - Ahmadzadehfar H AU - Khalaj A AU - Naseri M AU - Abbasi M TI - Clinical Use of 99Mtc-Hmpao-Labeled Platelets in Cerebral Sinus Thrombosis Imaging JO - Acta Neurologica Belgica VL - 119 IS - 4 SP - 549 EP - 553 PY - 2019 ER -

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