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Deciphering the Role of Erk and Pi3k/Akt As Crosstalk Pathways Between Fibroblast-Like Synoviocytes and Osteoclasts; Novel Therapeutic Approach for Rheumatoid Arthritis Publisher Pubmed



Ss Hassani Seyede SARA ; E Farhadi ELHAM ; Sa Esmaeili Seyed ALIREZA ; Mt Mahmoudi Mahdi T ; M Mahmoudi MAHMOUD ; Sj Tavakkol Afshari Seyed JALIL ; M Akhlaghi MASOUMEH ; Ar Jamshidi Ahmad REZA
Authors

Source: Molecular Biology Reports Published:2025


Abstract

Rheumatoid arthritis (RA) is a systemic immune-mediated synovial disorder characterized by chronic inflammation in the joints, resulting in heightened bone resorption and physical disabilities. RA develops through a complex interaction of different cellular and molecular factors. Fibroblast-like synoviocytes (FLSs), which have a significant role in the pathophysiology of RA, exhibiting an aggressive and inflammatory phenotype that leads to increased osteoclastogenesis and joint destruction. Understanding the cell-to-cell communication between osteoclasts and FLSs is essential for elucidating the pathophysiology of RA and identifying potential therapeutic targets for retrieving joint integrity and function. In this review, by studying the interactions of FLS and osteoclast in the inflammatory process of the disease, the ERK and PI3K/Akt pathways were found as common points in the activation of FLSs and osteoclastogenesis, which can be introduced as potential therapeutic targets in the experimental researches aimed at reducing bone destruction. © 2025 Elsevier B.V., All rights reserved.
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