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Fibrinogen Dysregulation Is a Prominent Process in Fatal Conditions of Covid-19 Infection; a Proteomic Analysis Publisher



Rezaeitavirani M1 ; Nejad MR2 ; Arjmand B3 ; Tavirani SR1 ; Razzaghi M4 ; Mansouri V1
Authors
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Authors Affiliations
  1. 1. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University ofMedical Sciences, Tehra, Iran
  2. 2. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University ofMedical Sciences, Tehran, Iran
  3. 3. Cell Therapy and RegenerativeMedicine Research Center, Endocrinology andMetabolismMolecular-Cellular Sciences Institute, Tehran University ofMedical Sciences, Tehran, Iran
  4. 4. Laser Application inMedical Sciences Research Center, Shahid Beheshti University ofMedical Sciences, Tehran, Iran

Source: Archives of Academic Emergency Medicine Published:2021


Abstract

Introduction: Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients’ plasma proteins have revealed new information about the disease. Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study. Methods: Significant differentially expressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an original article. These proteins were included in a network via STRING database along with 100 first neighbor proteins to determine central nodes of the network for analyzing. Results: Queried and added proteins were included in a scale free network. Three hub nodes were identified as critical target proteins. The top queried hub proteins were chains of fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and Fibrinogen beta chain (FGB), which are related to the coagulation process. Conclusion: It seems that fibrinogen dysregulation has a deep impact on the fatality of COVID-19 infection. © 2021. All Rights Reserved.
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