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A Rare Malignancy of the Eyelid: Report a Case of Primary Periocular Histiocytoid Carcinoma Publisher



Rahnavard A1 ; Mirzaian E2 ; Safaei R3 ; Mehrabi I1
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pathology, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

Source: Iranian Journal of Pathology Published:2024


Abstract

Primary periocular histiocytoid carcinoma is a very rare malignant tumor. Until now, less than 50 cases have been reported in the English literature. It is characterized by resistant epiphora, limitation in extraocular motility, and ptosis. The definitive diagnosis of this lesion is made based on detecting histological histiocytoid features along with tracing positivity of specific biomarkers using immunohistochemistry. However, pathologists may be faced with two major obstacles in the diagnosis of this tumor including distinguishing it from metastatic histiocytoid lesions and also from benign mimics such as reactive inflammatory lesions. Here, we describe a case of primary periocular histiocytoid carcinoma located on the eyelid as well as review the literature to clarify the histopathological and diagnostic features of this tumor. © 2024, Iranian Society of Pathology. All rights reserved.