Baseline Optical Coherence Tomography Angiography Biomarkers Predict Visual Outcomes in Treatment-Naive Neovascular Age-Related Macular Degeneration Patients Publisher Pubmed



Faghihi S¹ ; Faghihi H¹ ; Bazvand F¹ ; Mehrabi Bahar M¹ ; Torkashvand A² ; Husein Ahmed A¹ ; Rahimi M¹ ; Akbarzadeh A¹ ; Asadi Khameneh E¹ ; Khalili Pour E¹ ; Riaziesfahani H¹ Show Affiliations
Source: Scientific Reports Published:2024

Abstract

This retrospective study aimed to assess different macular neovascular network characteristics in relation to changes in best corrected visual acuity (BCVA) over 3 and 12 months following treatment. Using optical coherence tomography angiography, we reviewed the medical records of 46 treatment-naive patients with neovascular age-related macular degeneration (nAMD) who received intravitreal aflibercept injections. The change in BCVA from baseline to 3 months and 12 months after treatment was recorded. The mean vessels percentage area, junctions density, lacunarity, and fractal dimension were significantly correlated with the change of BCVA from baseline to month 3 (P = 0.003, 0.046, 0.007, and 0.005 respectively). Fractal dimension and vessels percentage area were correlated with the change of BCVA from baseline to month 12 (P = 0.023 and 0.023 respectively). The findings suggest that baseline characteristics of macular neovascular complexes may serve as predictors for BCVA changes following treatment with aflibercept in nAMD patients. © The Author(s) 2024.