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Cast Bronchitis in a Cystic Fibrosis Child: Experience With Direct Instillation of Dornase Alfa As an Adjunct Treatment Agent Publisher



Yousefzadegan S1 ; Shirzadi R1, 2 ; Navaie S1, 2 ; Takzare A3 ; Ghaempanah M1 ; Modaresi M1, 2
Authors
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Authors Affiliations
  1. 1. Pediatric Pulmonary and Sleep Medicine Department, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Pediatric Anesthesiology Department, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pediatrics Published:2019


Abstract

Introduction: Lobar atelectasis is one of the common problems in patients with cystic fibrosis and can be a cause of respiratory symptoms in these patients even in the absence of bacterial infection. Case Presentation: Here we introduce a 9-year-old boy with cystic fibrosis who had many admissions because of respiratory distress due to lung collapse mainly caused by plastic bronchitis. Conclusions: In a number of patients with cystic fibrosis, lobar atelectasis is seen which is resistant to medical treatments. Early fiberoptic bronchoscopy as a measure for mechanical removal of the blocking agent and sometimes direct injection of drugs like dornase alfa into the bronchus is a successful modality in the treatment of lobar collapses in chronic pulmonary diseases. © 2019, Author(s).