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A Tangible Prospect for the Treatment of Gingivitis Using a Potentially Probiotic Strain Lactobacillus Plantarum Mk06 Isolated From Traditional Dairy Products: A Triple Blind Randomized Clinical Trial Publisher Pubmed



Modiri S1 ; Heidari M2, 3 ; Shahmohammadi R4 ; Jabbareh L5 ; Maboudi A5 ; Moosazadeh M6 ; Vali H7 ; Noghabi KA1
Authors
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Authors Affiliations
  1. 1. National Institute of Genetic Engineering and Biotechnology (NIGEB), P. O. Box 14155-6343, Tehran, Iran
  2. 2. Department of Periodontology, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Implant Research Center, Dental Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Periodontology, Faculty of Dentistry, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Department of Anatomy & Cell Biology, McGill University, 3640 Street, Montreal, H3A 0C7, QC, Canada

Source: BMC Oral Health Published:2023


Abstract

Background: Frequent bacterial plaque buildup at the gingival margin and crevice can provoke an inflammatory reaction in gingival tissues which manifests as gingivitis. Probiotics could serve as a beneficial complementary therapy for treating gingival inflammation. The main aim of this research was to investigate the effect of the Lactobacillus plantarum MK06 probiotic strain on the treatment of gingivitis. Methods: Patients with gingivitis, who were referred to a private clinic and were systematically healthy, were included in this randomized, triple-blind, placebo-controlled trial. They were instructed to use either placebo or Lactobacillus plantarum suspensions for one minute two times a day after tooth-brushing for four weeks. Then, the clinical parameters of gingivitis, including plaque index (PI), gingival index (GI), bleeding on probing (BOP), and oral hygiene index (OHI-s), were measured in the first, second, and fourth weeks. A total of forty-two patients were randomly assigned to the experimental (n = 21) and control (n = 21) groups. The mean age of the experimental and control groups was 29.10 and 28.48, respectively. Results: The mean scores of BOP, GI, PI, and OHI-s reduced over time in both the control and test groups. However, according to the Mann-Whitney test, the difference between the two groups was not significant at the same time intervals (P ≥ 0.05) and only GI showed a significant difference in the fourth week (GI-3, P = 0.006). Nevertheless, the experimental group experienced a higher overall reduction rate than the control group. The BOP, GI, PI, and OHI-s scores decreased by 0.081, 0.204, 0.186, and 0.172 times in the second week, respectively, resulting from the interaction of time and the intervention, which considerably diminished these indices. Conclusion: This study shows the potential of the probiotic Lactobacillus plantarum MK06 suspension as a promoting therapeutic adjuvant in the treatment of gingivitis. © 2023, The Author(s).
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