The Association Between Triglyceride-Glucose Index and Contrast-Induced Nephropathy; a Systematic Review and Meta-Analysis Publisher



Safari M ; Kareem AK ; Rigi K ; Abbasi A ; Mokhtarinia B ; Pourpashang P ; Ahmadipour E ; Heydarisadegh B ; Aali H
Source: Journal of Nephropharmacology Published:2025

Abstract

Introduction: The triglyceride-glucose index (TyG) is an indicator of insulin resistance, which can cause chronic dysfunction in renal performance. Accordingly, the present study aimed to examine the association between high TyG index levels and the risk of contrast-induced nephropathy (CIN) using systematic review and meta-analysis methods. Materials and Methods: Searches were conducted across several databases, including Web of Science, Cochrane Library, ProQuest, PubMed, Embase, and Google Scholar. Data was analyzed using STATA 14 software, and tests with P < 0.05 were considered statistically significant. Results: High TyG index levels in total population (odds ratio [OR]: 2.24, 95% CI: 1.85, 2.71), in China (OR: 2.16, 95% CI: 1.76, 2.66), Turkey (OR: 2.77, 95% CI: 1.66, 4.6), cohort studies (OR: 2.13, 95% CI: 1.64, 2.78), case-control studies (OR: 2.59, 95% CI: 1.92, 3.51), and cross-sectional studies (OR: 2.17, 95% CI: 1.21, 3.89) increased the risk of CIN. On the other hand, the relationship between high TyG index levels among women (OR: 1.22, 95% CI: 0.84, 1.77) and CIN was insignificant. Furthermore, the association between high age (OR: 1.03, 95% CI: 1, 1.05), low-density lipoprotein (LDL) cholesterol (OR: 1.08, 95% CI: 1.03, 1.14), and eGFR (OR: 0.98, 95% CI: 0.96, 0.99) and the risk of CIN was statistically significant, but there was no significant relationship between blood hypertension (OR: 1.46, 95% CI: 0.95, 2.24), systolic blood pressure (SBP) (OR: 1.01, 95% CI: 0.99, 1.02), diastolic blood pressure (DBP) (OR: 1, 95% CI: 0.98, 1.03), diabetes mellitus (DM) (OR: 1.36, 95% CI: 0.58, 3.18), fasting blood glucose (FBG) (OR: 1.06, 95% CI: 0.97, 1.16), and hemoglobin (OR: 0.97, 95% CI: 0.94, 1.01) and the risk of CIN. Conclusion: High TyG index levels, high age, and LDL cholesterol levels increased the risk of CIN, indicating that the TyG index can be a strong predictor for the occurrence of CIN. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (ID: CRD420250651085)and Research Registry (UIN: reviewregistry1951) websites. © 2025 Elsevier B.V., All rights reserved.